4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase
In enzymology, a 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase (EC 1.2.1.45) is an enzyme that catalyzes the chemical reaction
- 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + NADP+ + H2O 4-carboxy-2-hydroxy-cis,cis-muconate + NADPH + 2 H+
| 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.2.1.45 | ||||||||
| CAS number | 67272-39-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The 3 substrates of this enzyme are 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde, NADP+, and H2O, whereas its 3 products are 4-carboxy-2-hydroxy-cis,cis-muconate, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ 6-oxidoreductase. Other names in common use include 2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+, oxidoreductase, alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde, and dehydrogenase. This enzyme participates in tyrosine metabolism and benzoate degradation via hydroxylation.
References
- Maruyama K, Ariga N, Tsuda M, Deguchi K (April 1978). "Purification and properties of alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase". J. Biochem. Tokyo. 83 (4): 1125–34. PMID 26671.