4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase

In enzymology, a 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase (EC 4.1.2.34) is an enzyme that catalyzes the chemical reaction

(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O 2-formylbenzoate + pyruvate
4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase
Identifiers
EC number4.1.2.34
CAS number86611-90-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate and H2O, whereas its two products are 2-formylbenzoate and pyruvate.

This enzyme participates in naphthalene and anthracene degradation.

Nomenclature

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-formylbenzoate-lyase (pyruvate-forming). Other names in common use include 2'-carboxybenzalpyruvate aldolase, (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate, 2-carboxybenzaldehyde-lyase, and (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-formylbenzoate-lyase.

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References
    • Barnsley EA (April 1983). "Phthalate pathway of phenanthrene metabolism: formation of 2'-carboxybenzalpyruvate". Journal of Bacteriology. 154 (1): 113–7. PMC 217437. PMID 6833175.


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