3-demethylubiquinone-9 3-O-methyltransferase

In enzymology, a 3-demethylubiquinone-9 3-O-methyltransferase (EC 2.1.1.64) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + 3-demethylubiquinone-9 S-adenosyl-L-homocysteine + ubiquinone-9
3-demethylubiquinone-9 3-O-methyltransferase
Identifiers
EC number2.1.1.64
CAS number63774-48-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are S-adenosyl methionine and 3-demethylubiquinone-9, whereas its two products are S-adenosylhomocysteine and ubiquinone-9.

This enzyme participates in ubiquinone biosynthesis.

Nomenclature

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1, 4-benzoquinone 3-O-methyltransferase. Other names in common use include 5-demethylubiquinone-9 methyltransferase, OMHMB-methyltransferase, 2-Octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone, methyltransferase, S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-, and 1,4-benzoquinone-O-methyltransferase.

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References
    • Houser RM, Olson RE (June 1977). "5-demethylubiquinone-9-methyltransferase from rat liver mitochondria. Characterization, localization, and solubilization". The Journal of Biological Chemistry. 252 (12): 4017–21. PMID 863914.
    • Leppik RA, Stroobant P, Shineberg B, Young IG, Gibson F (March 1976). "Membrane-associated reactions in ubiquinone biosynthesis. 2-Octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase". Biochimica et Biophysica Acta (BBA) - General Subjects. 428 (1): 146–56. doi:10.1016/0304-4165(76)90116-1. PMID 769831.


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