2-methylisoborneol synthase

2-methylisoborneol synthase (EC 4.2.3.118, sco7700, 2-MIB cyclase, MIB synthase, MIBS) is an enzyme with systematic name (E)-2-methylgeranyl-diphosphate diphosphate-lyase (cyclizing, 2-methylisoborneol-forming).[1][2][3] This enzyme catalyses the following chemical reaction

(E)-2-methylgeranyl diphosphate + H2O 2-methylisoborneol + diphosphate
2-methylisoborneol synthase
Identifiers
EC number4.2.3.118
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The product, 2-methylisoborneol, is a characteristic odiferous compound with a musty smell produced by soil microorganisms.

References

  1. Wang CM, Cane DE (July 2008). "Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor". Journal of the American Chemical Society. 130 (28): 8908–9. doi:10.1021/ja803639g. PMC 3023297. PMID 18563898.
  2. Komatsu M, Tsuda M, Omura S, Oikawa H, Ikeda H (May 2008). "Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol". Proceedings of the National Academy of Sciences of the United States of America. 105 (21): 7422–7. doi:10.1073/pnas.0802312105. PMC 2387273. PMID 18492804.
  3. Giglio S, Chou WK, Ikeda H, Cane DE, Monis PT (February 2011). "Biosynthesis of 2-methylisoborneol in cyanobacteria". Environmental Science & Technology. 45 (3): 992–8. doi:10.1021/es102992p. PMC 3699865. PMID 21174459.
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