2-hydroxyhexa-2,4-dienoate hydratase
2-hydroxyhexa-2,4-dienoate hydratase (EC 4.2.1.132, tesE (gene), hsaE (gene)) is an enzyme with systematic name 4-hydroxy-2-oxohexanoate hydro-lyase ((2Z,4Z)-2-hydroxyhexa-2,4-dienoate-forming).[1] This enzyme catalyses the following chemical reaction
- 4-hydroxy-2-oxohexanoate (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O
| 2-hydroxyhexa-2,4-dienoate hydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.1.132 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme catalyses a late step in the bacterial steroid degradation pathway.
References
- Horinouchi M, Hayashi T, Koshino H, Kurita T, Kudo T (September 2005). "Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441". Applied and Environmental Microbiology. 71 (9): 5275–81. doi:10.1128/aem.71.9.5275-5281.2005. PMC 1214608. PMID 16151114.
External links
- 2-hydroxyhexa-2,4-dienoate+hydratase at the US National Library of Medicine Medical Subject Headings (MeSH)
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