2-hydroxyethylphosphonate dioxygenase
2-hydroxyethylphosphonate dioxygenase (EC 1.13.11.72, HEPD, phpD (gene)) is an enzyme with systematic name 2-hydroxyethylphosphonate:O2 1,2-oxidoreductase (hydroxymethylphosphonate forming).[1][2][3] This enzyme catalyses the following chemical reaction
- 2-hydroxyethylphosphonate + O2 hydroxymethylphosphonate + formate
| 2-hydroxyethylphosphonate dioxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.13.11.72 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
2-hydroxyethylphosphonate dioxygenase contains non-heme-Fe(II).
References
- Cicchillo RM, Zhang H, Blodgett JA, Whitteck JT, Li G, Nair SK, van der Donk WA, Metcalf WW (June 2009). "An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis". Nature. 459 (7248): 871–4. doi:10.1038/nature07972. PMC 2874955. PMID 19516340.
- Whitteck JT, Malova P, Peck SC, Cicchillo RM, Hammerschmidt F, van der Donk WA (March 2011). "On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase". Journal of the American Chemical Society. 133 (12): 4236–9. doi:10.1021/ja1113326. PMC 3069692. PMID 21381767.
- Peck SC, Cooke HA, Cicchillo RM, Malova P, Hammerschmidt F, Nair SK, van der Donk WA (August 2011). "Mechanism and substrate recognition of 2-hydroxyethylphosphonate dioxygenase". Biochemistry. 50 (30): 6598–605. doi:10.1021/bi200804r. PMC 3143709. PMID 21711001.
External links
- 2-hydroxyethylphosphonate+dioxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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