2-dehydro-3-deoxy-D-pentonate aldolase
In enzymology, a 2-dehydro-3-deoxy-D-pentonate aldolase (EC 4.1.2.28) is an enzyme that catalyzes the chemical reaction
- 2-dehydro-3-deoxy-D-pentonate pyruvate + glycolaldehyde
| 2-dehydro-3-deoxy-D-pentonate aldolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.1.2.28 | ||||||||
| CAS number | 55326-36-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Hence, this enzyme has one substrate, 2-dehydro-3-deoxy-D-pentonate, and two products, pyruvate and glycolaldehyde.
This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-pentonate glycolaldehyde-lyase (pyruvate-forming). Other names in common use include 2-keto-3-deoxy-D-pentonate aldolase, 3-deoxy-D-pentulosonic acid aldolase, and 2-dehydro-3-deoxy-D-pentonate glycolaldehyde-lyase. This enzyme participates in pentose and glucuronate interconversions.
References
- Dahms AS (1974). "3-Deoxy-D-pentulosonic acid aldolase and its role in a new pathway of D-xylose degradation". Biochem. Biophys. Res. Commun. 60 (4): 1433–9. doi:10.1016/0006-291X(74)90358-1. PMID 4423285.
- Dahms AS, Donald A (1982). "2-Keto-3-deoxy-d-xylonate aldolase (3-deoxy-d-pentulosonic acid aldolase)". Methods Enzymol. 90 Pt. E: 269–72. PMID 7154955.
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