2,3-dimethylmalate lyase

In enzymology, a 2,3-dimethylmalate lyase (EC 4.1.3.32) is an enzyme that catalyzes the chemical reaction

(2R,3S)-2,3-dimethylmalate propanoate + pyruvate
2,3-dimethylmalate lyase
Identifiers
EC number4.1.3.32
CAS number73562-28-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Hence, this enzyme has one substrate, (2R,3S)-2,3-dimethylmalate, and two products, propanoate and pyruvate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (2R,3S)-2,3-dimethylmalate pyruvate-lyase (propanoate-forming). Other names in common use include 2,3-dimethylmalate pyruvate-lyase, and (2R,3S)-2,3-dimethylmalate pyruvate-lyase. This enzyme participates in c5-branched dibasic acid metabolism.

References

    • Pirzer P, Lill U, Eggerer H (1979). "Nicotinic acid metabolism. 2,3-Dimethylmalate lyase". Hoppe-Seyler's Z. Physiol. Chem. 360 (12): 1693–702. doi:10.1515/bchm2.1979.360.2.1693. PMID 527937.
    • Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ (2006). "Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri". Proc. Natl. Acad. Sci. U.S.A. 103 (33): 12341–6. doi:10.1073/pnas.0601635103. PMC 1562527. PMID 16894175.


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