(-)-alpha-cuprenene synthase

(-)-alpha-cuprenene synthase (EC 4.2.3.95, Cop6) is an enzyme with systematic name (-)-alpha-cuprenene hydrolase (cyclizing, (-)-alpha-cuprenene-forming).[1] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate (-)-alpha-cuprenene + diphosphate
(-)-alpha-cuprenene synthase
Identifiers
EC number4.2.3.95
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme from the fungus Coprinopsis cinerea produces (-)-alpha-cuprenene with high selectivity.

References

  1. Lopez-Gallego F, Agger SA, Abate-Pella D, Distefano MD, Schmidt-Dannert C (May 2010). "Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers". ChemBioChem. 11 (8): 1093–106. doi:10.1002/cbic.200900671. PMC 2873112. PMID 20419721.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.