(+)-epicubenol synthase

(+)-epicubenol synthase (EC 4.2.3.64, farnesyl pyrophosphate cyclase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((+)-epicubenol-forming).[1][2][3][4][5] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate + H2O (+)-epicubenol + diphosphate
(+)-epicubenol synthase
Identifiers
EC number4.2.3.64
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme requires Mg2+.

References
  1. Cane DE, Tandon M, Prabhakaran PC (1993). "Epicubenol synthase and the enzymatic cyclization of farnesyl diphosphate". J. Am. Chem. Soc. 115: 8103–8106. doi:10.1021/ja00071a023.
  2. Cane DE, Tandon M (1994). "Biosynthesis of (+)-epicubenol". Tetrahedron Lett. 35: 5355–5358. doi:10.1016/s0040-4039(00)73498-8.
  3. Cane DE, Tandon M (1995). "Epicubenol synthase and the stereochemistry of the enzymatic cyclization of farnesyl and nerolidyl diphosphate". J. Am. Chem. Soc. 117: 5602–5603. doi:10.1021/ja00125a029.
  4. Nabeta K, Kigure K, Fujita M, Nagoya T, Ishikawa T, Okuyama H, Takasawa T (1995). "Bioynthesis of (+)-cubenene and (+)-epicubenol by cell-free extracts of cultured cells of Heteroscyphus planus and cyclization of [2H]farnesyl diphosphates". J. Chem. Soc., Perkin Trans. 1: 1935–1939. doi:10.1039/p19950001935.
  5. Nabeta K, Fujita M, Komuro K, Katayama K, Takasawa T (1997). "In vitro biosynthesis of cadinanes by cell-free extracts of cultured cells of Heteroscyphus planus". J. Chem. Soc., Perkin Trans. 1: 2065–2070. doi:10.1039/a701145h.
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