(+)-epi-alpha-bisabolol synthase

(+)-epi-alpha-bisabolol synthase (EC 4.2.3.138) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-epi-alpha-bisabolol-forming).[1] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate + H2O (+)-epi-alpha-bisabolol + diphosphate
(+)-epi-alpha-bisabolol synthase
Identifiers
EC number4.2.3.138
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is isolated from the plant Phyla dulcis (Aztec sweet herb).

References

  1. Attia M, Kim SU, Ro DK (November 2012). "Molecular cloning and characterization of (+)-epi-α-bisabolol synthase, catalyzing the first step in the biosynthesis of the natural sweetener, hernandulcin, in Lippia dulcis". Archives of Biochemistry and Biophysics. 527 (1): 37–44. doi:10.1016/j.abb.2012.07.010. PMID 22867794.
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