Ro 3-0419

Ro 3-0419 is a highly toxic organophosphate acetylcholinesterase inhibitor. It's the neutral analog of Ro 3-0422. Although Ro 3-0419 is less potent than Ro 3-0422, it does not have a positively charged nitrogen atom, so it's able to cross the blood brain barrier to inhibit cholinesterases in the brain. The intravenous LD₅₀ of Ro 3-0419 is 1 mg/kg in mice.[1]

Ro 3-0419

Names
IUPAC name Diethyl 3-quinolinyl phosphate
Other names 3-(Diethoxyphosphinyloxy)-quinoline
Identifiers
3D model (JSmol)	Interactive image
ChemSpider	2295246
PubChem CID	3029999
InChI InChI=1S/C13H16NO4P/c1-3-16-19(15,17-4-2)18-12-9-11-7-5-6-8-13(11)14-10-12/h5-10H,3-4H2,1-2H3 Key: LHRQAYKGKTYZRY-UHFFFAOYSA-N
SMILES CCOP(=O)(OCC)Oc1cc2ccccc2nc1
Properties
Chemical formula	C13H16NO4P
Molar mass	281.248 g·mol^−1
Hazards
Main hazards	Highly toxic
Lethal dose or concentration (LD, LC):
LD50 (median dose)	1 mg/kg (mice, intravenous)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

See also

• Ro 3-0422

References

1. HOBBIGER, F (June 1954). "The inhibition of cholinesterases by 3-(diethoxyphosphinyloxy)-N-methylquinolinium methylsulphate and its tertiary base". British Journal of Pharmacology and Chemotherapy. 9 (2): 159–65. doi:10.1111/j.1476-5381.1954.tb00835.x. PMC 1509437. PMID 13172424.