Yt antigen system

The Yt antigen system (also known as Cartwright) is present on the membrane of red blood cells and helps determine a person's blood type. The antigens are found on the protein acetylcholinesterase, an enzyme which helps break down acetylcholine.[1] The Yt system features two alleles, Yt(a) and Yt(b). Antibodies against the Yt system can lead to transfusion reactions such as hemolytic anemia.

References

Online Mendelian Inheritance in Man (OMIM): 112100 - OMIM page on Yt antigen

  1. Bartels, CF; Zelinski, T; Lockridge, O (1993). "Mutation at codon 322 in the human acetylcholinesterase (ACHE) gene accounts for YT blood group polymorphism". American Journal of Human Genetics. 52 (5): 928–36. PMC 1682033. PMID 8488842.
  • Yt at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH
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