Yapsin 1

Yapsin 1 (EC 3.4.23.41, yeast aspartic protease 3, Yap3 gene product (Saccharomyces cerevisiae)) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Hydrolyses various precursor proteins with Arg or Lys in P1, and commonly Arg or Lys also in P2. The P3 amino acid is usually non-polar, but otherwise additional basic amino acids are favourable in both non-prime and prime positions
Yapsin 1
Identifiers
EC number3.4.23.41
CAS number205132-58-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme belongs to the peptidase family A1 of pepsin.

References

  1. Cawley NX, Chen HC, Beinfeld MC, Loh YP (February 1996). "Specificity and kinetic studies on the cleavage of various prohormone mono- and paired-basic residue sites by yeast aspartic protease 3". The Journal of Biological Chemistry. 271 (8): 4168–76. doi:10.1074/jbc.271.8.4168. PMID 8626758.
  2. Fuller RS, Rawlings ND, Woessner JF (1998). "Yapsin 2". In Barrett AJ (ed.). Handbook of Proteolytic Enzymes. London: Academic Press. pp. 908–909.
  3. Olsen V, Guruprasad K, Cawley NX, Chen HC, Blundell TL, Loh YP (March 1998). "Cleavage efficiency of the novel aspartic protease yapsin 1 (Yap3p) enhanced for substrates with arginine residues flanking the P1 site: correlation with electronegative active-site pockets predicted by molecular modeling". Biochemistry. 37 (9): 2768–77. doi:10.1021/bi9724826. PMID 9485427.
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