Tupavirus

Tupavirus is a genus of viruses in the family Rhabdoviridae, order Mononegavirales.[1][2]

Not to be confused with Tupanvirus.

Tupavirus
Virus classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Class: Monjiviricetes
Order: Mononegavirales
Family: Rhabdoviridae
Genus: Tupavirus
Type species
Durham tupavirus
Species
  • Durham tupavirus
  • Klamath tupavirus
  • Tupaia tupavirus

Taxonomy
Genus Tupavirus: species and their viruses[3]
Genus Species Virus (Abbreviation)
Tupavirus Durham tupavirus* Durham virus (DURV)
Tupaia tupavirus tupaia virus (TUPV)

Table legend: "*" denotes type species.

Structure

Tupavirions enveloped, with bullet shaped geometries. These particles are about 160 nm long. Tupavirus genomes are linear, around 11.2 kb in length. The genome codes for 7 proteins.[1]

GenusStructureSymmetryCapsidGenomic arrangementGenomic segmentation
TupavirusBullet-shapedEnvelopedLinear

Life cycle

Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the viral G glycoproteins to host receptors, which mediates clathrin-mediated endocytosis. Replication follows the negative stranded RNA virus replication model. Negative stranded RNA virus transcription, using polymerase stuttering is the method of transcription. The virus exits the host cell by budding, and tubule-guided viral movement. Birds serve as the natural host for Durham tupavirus[1], with antibodies having been found in the American Coot (Fulica americana)[4]. Additionally, antibodies for Klamath tupavirus have been found in several species of deer, bison, and humans.[4], as well as voles and shrews[4].

GenusHost detailsTissue tropismEntry detailsRelease detailsReplication siteAssembly siteTransmission
TupavirusBirdsNoneClathrin-mediated endocytosisBuddingCytoplasmCytoplasmUnknown
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References
  1. "Viral Zone". ExPASy. Retrieved 13 August 2015.
  2. ICTV. "Virus Taxonomy: 2014 Release". Retrieved 13 August 2015.
  3. Afonso, Claudio L.; Amarasinghe, Gaya K.; Bányai, Krisztián; Bào, Yīmíng; Basler, Christopher F.; Bavari, Sina; Bejerman, Nicolás; Blasdell, Kim R.; Briand, François-Xavier (1 August 2016). "Taxonomy of the order Mononegavirales: update 2016". Archives of Virology. 161 (8): 2351–2360. doi:10.1007/s00705-016-2880-1. ISSN 1432-8798. PMC 4947412. PMID 27216929.
  4. ICTV. "Genus: Tupavirus". Retrieved 12 August 2019.
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