Trimethoprim/sulfadoxine

Trimethoprim/sulfadoxine
Combination of
Trimethoprim	Dihydrofolate reductase inhibitor
Sulfadoxine	Sulfonamide antibiotic
Clinical data
Trade names	Trimidox

Trimethoprim/sulfadoxine, sold under the brand name Trimidox, is an antibacterial agent that is used in cattle and swine to prevent and treat infections by both Gram-negative and Gram-positive bacteria.[1]

Veterinary uses

Trimethoprim/sulfadoxine is used in the treatment of swine and cattle; including dairy cattle, beef cattle and veal.

In cattle, it is used to treat:

Respiratory tract infections such as, bovine pneumonia pasteurellosis (shipping fever)[1]
Alimentary tract infections such as salmonellosis and both enteric and septicaemic colibacillosis.[1]
Other infections such as pododermatitis (foot rot) and septicaemias.[1]

In swine, it is used to treat:

Respiratory tract infections such as, bacterial pneumonias.[1]
Alimentary tract infections such as, post-weaning scours and colibacillosis.[1]
Other infections such as bacterial arthritis and mastitis-metritis-agalactia syndrome in sows.[1]

Contraindications

Trimethoprim/sulfadoxine is contraindicated in cattle or swine that show marked liver parenchymal damage or blood dyscrasias, or those with a history of sulfonamide sensitivity.[1]

Milk from an animal treated with trimethoprim/sulfadoxine must not be consumed for at least 96 hours following the most recent treatment; treated animals must not be slaughtered for use in food for at least ten days after the last treatment.[1]

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References

"Trimidox". Vetoquinol Canada Inc. Retrieved 11 November 2011.

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[drugs_com-1] "Trimidox". Vetoquinol Canada Inc. Retrieved 11 November 2011.