Taurocholic acid
Taurocholic acid, known also as cholaic acid, cholyltaurine, or acidum cholatauricum, is a deliquescent yellowish crystalline bile acid involved in the emulsification of fats. It occurs as a sodium salt in the bile of mammals. It is a conjugate of cholic acid with taurine. In medical use, it is administered as a cholagogue and choleretic.[1]
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IUPAC name
2-{[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}ethanesulfonic acid | |
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ECHA InfoCard | 100.001.216 |
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CompTox Dashboard (EPA) |
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Properties | |
C26H45NO7S | |
Molar mass | 515.7058 g/mol |
Melting point | 125.0 °C (257.0 °F; 398.1 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Hydrolysis of taurocholic acid yields taurine.
For commercial use, taurocholic acid is manufactured from cattle bile, a byproduct of the meat-processing industry.[2]
This acid is also one of the many molecules in the body that has cholesterol as its precursor.
Toxicity
The median lethal dose of taurocholic acid in newborn rats is 380 mg/kg.
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gollark: Wait, does the wiki have some sort of idiomatic formatting style <@278889690596376576>?
gollark: this is not a forum
gollark: seriously why reserve posts
See also
References
- Anwer, M. Sawkat (2004). "Cellular regulation of hepatic bile acid transport in health and cholestasis". Hepatology. 39 (3): 581–590. doi:10.1002/hep.20090. PMID 14999673.
- Taurocholic acid, sodium salt Archived 2009-04-21 at the Wayback Machine at GlycoFineChem.com
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