Transfusion-related acute lung injury

Transfusion-related acute lung injury (TRALI) is a serious blood transfusion complication characterized by the acute onset of non-cardiogenic pulmonary edema following transfusion of blood products.[1]

Transfusion-related acute lung injury
Other namesTRALI
Micrograph of diffuse alveolar damage, the histologic correlate of TRALI; H&E stain
SpecialtyPulmonology

Although the incidence of TRALI has decreased with modified transfusion practices, it was the leading cause of transfusion-related deaths in the United States from fiscal year 2008 through fiscal year 2012.[2]

Signs and symptoms

It is often impossible to distinguish TRALI from acute respiratory distress syndrome (ARDS). The typical presentation of TRALI is the sudden development of dyspnea, severe hypoxemia (O2 saturation <90% in room air), hypotension, and fever that develop within 6 hours after transfusion and usually resolve with supportive care within 48 to 96 hours. Although hypotension is considered one of the important signs in diagnosing TRALI, hypertension can occur in some cases.[3]

Cause

The cause of TRALI is currently not fully understood. 80-85% of cases are thought to be immune mediated.[4][5][6] Antibodies directed toward human leukocyte antigens (HLA) or human neutrophil antigens (HNA) have been implicated. Women who are multiparous (conceived more than one child) develop these antibodies through exposure to fetal blood; transfusion of blood components obtained from these donors is thought to carry a higher risk of inducing immune-mediated TRALI.[6] Previous transfusion or transplantation can also lead to donor sensitization. To be at risk of TRALI via this mechanism, the blood recipient must express the specific HLA or neutrophil receptors to which the implicated donor has formed antibodies. A two-hit hypothesis has been suggested[7] wherein pre-existing pulmonary pathology (i.e. the first-hit) leads to localization of neutrophils to the pulmonary microvasculature. The second hit occurs when the aforementioned antibodies are transfused and attach to and activate neutrophils, leading to release of cytokines and vasoactive substances that induce non-cardiac pulmonary edema.

A non-immune mechanism has been studied and proposed by Silliman, involving the accumulation of bioactive lipids in stored blood components (red cells, platelets, plasma) that possess neutrophil priming capabilities.[3]

TRALI is typically associated with plasma products such as FFP. TRALI can also occur in recipients of packed red blood cells both in adult and pediatric patients.[8] The AABB (formerly the American Association of Blood Banks) recommended on 11/03/2006 in association bulletin 06-07 that blood banks use high plasma volume components from female donors for further manufacturing instead of transfusion due to the higher risk of TRALI.[9]

Pathophysiology

In TRALI, first-hit risk factors include chronic alcohol abuse, shock, liver surgery, current smoking, higher peak airway pressure while undergoing mechanical ventilation, positive intravascular fluid balance, low interleukin-10 (IL-10) levels, and systemic inflammation. Systemic inflammation may be reflected in the plasma cytokine profiles but also via increased levels of C-reactive protein (CRP). CRP is an acute-phase protein that rapidly increases during acute infections and inflammation and is widely used in clinic as an inflammatory biomarker. CRP was shown to be elevated in TRALI patients and functionally enabled the first hit in the development of TRALI in a murine model by increasing the levels of the neutrophil (PMN)-chemoattractant macrophage inflammatory protein (MIP)-2 (murine homolog of IL-8), resulting in increased pulmonary PMN accumulation. Pre-existing pulmonary injury, which causes white blood cell localization to the pulmonary vasculature, also predisposes to TRALI. [10]The second hit in TRALI may be conveyed by anti-leukocyte antibodies or other factors present in the transfusion product. In approximately 80% of cases, anti-HLA class I or II or anti-HNA antibodies are implicated to be involved in triggering TRALI, although this may be even higher depending on the detection methods used. In the remaining 20% of TRALI cases, non–antibody factors/biological response modifiers are suggested to contribute the second hit, and these may possibly include lipid mediators, extracellular vesicles, and aged blood cells.[11]

Diagnosis
Chest X-ray of transfusion-related acute lung injury (TRALI) compared to chest X-ray of the same person after treatment

TRALI is defined as an acute lung injury that is temporally related to a blood transfusion; specifically, it occurs within the first six hours following a transfusion.[12]

It is typically associated with plasma components such as platelets and fresh frozen plasma, though cases have been reported with packed red blood cells since there is some residual plasma in the packed cells.[9]

It is a diagnosis upon examination of clinical manifestations that appear within 6 hours of transfusion, such as acute respiratory distress, tachypnea, hypotension, cyanosis, and dyspnea. TRALI is an uncommon syndrome, that is due to the presence of leukocyte antibodies in transfused plasma. It is believed to occur in approximately one in every 5000 transfusions.[3] Leukoagglutination and pooling of granulocytes in the recipient's lungs may occur, with release of the contents of leukocyte granules, and resulting injury to cellular membranes, endothelial surfaces, and potentially to lung parenchyma. In most cases leukoagglutination results in mild dyspnea and pulmonary infiltrates within about 6 hours of transfusion, and spontaneously resolves.

Occasionally more severe lung injury occurs as a result of this phenomenon and acute respiratory distress syndrome (ARDS) results. Leukocyte filters may prevent TRALI for those patients whose lung injury is due to leukoagglutination of the donor white blood cells, but because most TRALI is due to donor antibodies to leukocytes, filters are not helpful in TRALI prevention. Transfused plasma (from any component source) may also contain antibodies that cross-react with platelets in the recipient, producing usually mild forms of posttransfusion purpura or platelet aggregation after transfusion.

Another nonspecific form of immunologic transfusion complication is mild to moderate immunosuppression consequent to transfusion. This effect of transfusion is not completely understood, but appears to be more common with cellular transfusion and may result in both desirable and undesirable effects. Mild immunosuppression may benefit organ transplant recipients and patients with autoimmune diseases; however, neonates and other already immunosuppressed hosts may be more vulnerable to infection, and cancer patients may possibly have worse outcomes postoperatively.

Treatment

Supportive care is the mainstay of therapy in TRALI. Oxygen supplementation is employed in all reported cases of TRALI and aggressive respiratory support is needed in 72 percent of patients. Intravenous administration of fluids, as well as vasopressors, are essential for blood pressure support. Use of diuretics, which are indicated in the management of transfusion associated circulatory overload (TACO), should be avoided in TRALI. Corticosteroids can be beneficial.

Epidemiology

The true incidence of TRALI is unknown because of the difficulty in making the diagnosis and because of underreporting. It is estimated to occur in 1:1300 to 1:5000 transfusions of plasma-containing products. TRALI is the leading reported cause of death related to transfusion in the United States; more than 20 cases were reported per year from 2003 to 2005. The immune mediated form of TRALI occurs approximately once every 5000 transfusions and has a mortality of 6–9%.[13]

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See also
  • Flash pulmonary edema

References
  1. Gajic, Ognjen; Moore, S. Breanndan (2005). "Transfusion-Related Acute Lung Injury". Mayo Clinic Proceedings. 80 (6): 766–770. doi:10.1016/S0025-6196(11)61531-0. PMID 15945528.
  2. U.S. Food and Drug Administration, Center for Biologics Evaluation and Research. Fatalities Reported to FDA Following Blood Collection and Transfusion: Annual Summary for Fiscal Year 2012. Bethesda, Md: U.S. Food and Drug Administration.
  3. Silliman, C. C.; Fung, Y. L.; Ball, J. B.; Khan, S. Y. (2009). "Transfusion-related acute lung injury (TRALI): Current Concepts and Misconceptions". Blood Reviews. 23 (6): 245–255. doi:10.1016/j.blre.2009.07.005. PMC 3134874. PMID 19699017.
  4. https://professionaleducation.blood.ca/en/transfusion/publications/transfusion-related-acute-lung-injury-trali
  5. Dykes, A.; Smallwood, D.; Kotsimbos, T.; Street, A. (2000). "Transfusion-Related Acute Lung Injury (Trali) In A Patient With A Single Lung Transplant". British Journal of Haematology. 109 (3): 674–6. doi:10.1046/j.1365-2141.2000.01999.x. PMID 10886228.
  6. Muller, J.Y. (2005). "Le TRALI : du diagnostic à la prévention" [TRALI: from diagnosis to prevention]. Transfusion Clinique et Biologique (in French). 12 (2): 95–102. doi:10.1016/j.tracli.2005.04.007. PMID 15894508. INIST:16924693.
  7. Silliman, Christopher C. (2006). "The two-event model of transfusion-related acute lung injury". Critical Care Medicine. 34 (5 Suppl): S124–131. doi:10.1097/01.CCM.0000214292.62276.8E. ISSN 0090-3493. PMID 16617256.
  8. Cudilo, Elizabeth M.; Varughese, Anna M.; Mahmoud, Mohamed; Carey, Patricia M.; Subramanyam, Rajeev; Lerman, Jerrold (2015). "Case report of transfusion-related acute lung injury in a pediatric spine surgery patient transfused leukoreduced red blood cells". Pediatric Anesthesia. 25 (12): 1294–7. doi:10.1111/pan.12696. PMID 26126598.
  9. Association Bulletin #14-02. TRALI Risk Mitigation for Plasma and Whole Blood for Allogeneic Transfusion. Bethesda: AABB; 1/29/2014
  10. Kleinman S, Kor DJ. “Transfusion-related acute lung injury (TRALI).” In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Last updated 5/11/17. Accessed via http://www.uptodate.com/contents/transfusion-related-acute-lung-injury-trali on 6/28/17.
  11. Semple, John W.; Rebetz, Johan; Kapur, Rick (April 25, 2019). "Transfusion-associated circulatory overload and transfusion-related acute lung injury". Blood. 133 (17): 1840–1853. doi:10.1182/blood-2018-10-860809. ISSN 1528-0020. PMID 30808638.
  12. Toy P, Popovsky MA, Abraham E, Ambruso DR, Holness LG, Kopko PM, McFarland JG, Nathens AB, Silliman CC, Stroncek D (2005). "Transfusion-related acute lung injury: definition and review". Critical Care Medicine. 33 (4): 721–6. doi:10.1097/01.ccm.0000159849.94750.51. PMID 15818095.
  13. Bux, J. (2005). "Transfusion-related acute lung injury (TRALI): a serious adverse event of blood transfusion". Vox Sanguinis. 89 (1): 1–10. doi:10.1111/j.1423-0410.2005.00648.x. PMID 15938734.


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