TIMM44

Mitochondrial import inner membrane translocase subunit TIM44 is an enzyme that in humans is encoded by the TIMM44 gene.[5][6][7]

TIMM44
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CW9
Identifiers
Aliases	TIMM44, TIM44, translocase of inner mitochondrial membrane 44
External IDs	OMIM: 605058 MGI: 1343262 HomoloGene: 4631 GeneCards: TIMM44
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 7,926,718 bp[1] End 7,943,667 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A1.1|8 1.99 cM Start 4,259,731 bp[2] End 4,275,913 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • chaperone binding • GO:0001948 protein binding • ATP binding Cellular component • mitochondrial inner membrane • membrane • mitochondrion • mitochondrial matrix Biological process • protein transport • protein targeting to mitochondrion • protein import into mitochondrial matrix Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10469	21856
Ensembl	ENSG00000104980	ENSMUSG00000002949
UniProt	O43615	O35857
RefSeq (mRNA)	NM_006351	NM_011592
RefSeq (protein)	NP_006342	NP_035722
Location (UCSC)	Chr 19: 7.93 – 7.94 Mb	Chr 8: 4.26 – 4.28 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TIMM44 has been shown to interact with ARAF.[5][8]

See also

• Mitochondria Inner Membrane Translocase
• TIMM17A
• TIMM22
• TIMM23

References

1. GRCh38: Ensembl release 89: ENSG00000104980 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002949 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yuryev A, Ono M, Goff SA, Macaluso F, Wennogle LP (Jul 2000). "Isoform-Specific Localization of A-RAF in Mitochondria". Mol Cell Biol. 20 (13): 4870–8. doi:10.1128/MCB.20.13.4870-4878.2000. PMC 85938. PMID 10848612.
6. Bauer MF, Gempel K, Reichert AS, Rappold GA, Lichtner P, Gerbitz KD, Neupert W, Brunner M, Hofmann S (Jul 1999). "Genetic and structural characterization of the human mitochondrial inner membrane translocase". J Mol Biol. 289 (1): 69–82. doi:10.1006/jmbi.1999.2751. PMID 10339406.
7. "Entrez Gene: TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast)".
8. Yuryev, Anton; Wennogle Lawrence P (Feb 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. United States. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. ISSN 0888-7543. PMID 12620389.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Moro F, Sirrenberg C, Schneider HC, et al. (1999). "The TIM17.23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix". EMBO J. 18 (13): 3667–75. doi:10.1093/emboj/18.13.3667. PMC 1171444. PMID 10393182.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yuryev A, Wennogle LP (2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Mitochondrial import inner membrane translocase subunit TIM44