TIMM22

Mitochondrial import inner membrane translocase subunit Tim22 is an enzyme that in humans is encoded by the TIMM22 gene.[5]

TIMM22
Identifiers
Aliases	TIMM22, TEX4, TIM22, translocase of inner mitochondrial membrane 22 homolog (yeast), translocase of inner mitochondrial membrane 22, COXPD43
External IDs	OMIM: 607251 MGI: 1929742 HomoloGene: 32173 GeneCards: TIMM22
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.3 Start 997,129 bp[1] End 1,003,671 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B5 Start 76,406,952 bp[2] End 76,416,292 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • mitochondrion targeting sequence binding • GO:0001948 protein binding • protein transmembrane transporter activity Cellular component • integral component of membrane • mitochondrial inner membrane • membrane • mitochondrion • TIM22 mitochondrial import inner membrane insertion complex Biological process • protein transport • protein targeting to mitochondrion • protein import into mitochondrial inner membrane • protein transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29928	56322
Ensembl	ENSG00000277649 ENSG00000278501 ENSG00000177370	ENSMUSG00000020843
UniProt	Q9Y584	Q9CQ85
RefSeq (mRNA)	NM_013337	NM_001291161 NM_019818 NM_023355
RefSeq (protein)	NP_037469	NP_001278090 NP_062792 NP_075844
Location (UCSC)	Chr 17: 1 – 1 Mb	Chr 11: 76.41 – 76.42 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Mitochondria Inner Membrane Translocase
• TIMM17A
• TIMM23
• TIMM44

References

1. ENSG00000278501, ENSG00000177370 GRCh38: Ensembl release 89: ENSG00000277649, ENSG00000278501, ENSG00000177370 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020843 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mühlenbein N, Hofmann S, Rothbauer U, Bauer MF (2004). "Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria". J. Biol. Chem. 279 (14): 13540–6. doi:10.1074/jbc.M312485200. PMID 14726512.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kovermann P, Truscott KN, Guiard B, et al. (2002). "Tim22, the essential core of the mitochondrial protein insertion complex, forms a voltage-activated and signal-gated channel". Mol. Cell. 9 (2): 363–73. doi:10.1016/S1097-2765(02)00446-X. PMID 11864609.
• Bauer MF, Rothbauer U, Mühlenbein N, et al. (2000). "The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom". FEBS Lett. 464 (1–2): 41–7. doi:10.1016/S0014-5793(99)01665-8. PMID 10611480.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.