Sujata Sharma

Sujata Sharma is an Indian structural biologist, biophysicist and a professor at the Department of Biophysics of the All India Institute of Medical Sciences, Delhi.[1] She is known for her studies in the fields of protein structure, drug design and drug resistance of bacteria.[2] Her studies have been documented by way of a number of articles[note 1] and ResearchGate, an online repository of scientific articles has listed 167 of them.[1] She is also the author of the books, The Secret of the Red Crystals, an autobiographical account of her days in AIIMS Delhi.[3] and "A Dragonfly's purpose", which is an autobiographical account of her recovery from an autoimmune disease, Guillain Barre Syndrome [4]. The Department of Biotechnology of the Government of India awarded her the National Bioscience Award for Career Development, one of the highest Indian science awards, for her contributions to biosciences, in 2011.[5] She is also a recipient of the Woman Scientist Award of the Biotech Research Society of India[6] and the National Young Woman Bioscientist Award of the Department of Biotechnology which she received in 2006 and 2007 respectively.[7] In 2020, she was awarded the Kalpana Chawla Excellence award [8] , for her contributions in science. This award is instituted in the memory of the first Indian woman astronaut, Kalpana Chawla to go on space missions.

Sujata Sharma
Born (1970-06-18) 18 June 1970
India
Alma mater
  • AIIMS Delhi
Known forLactoferrin, Acinetobacter baumannii, Lactoperoxidase, Peptidoglycan REcgnition Protein
Awards
Scientific career
Fields
Institutions
  • AIIMS Delhi

Contributions in Structural Biology

Sujata Sharma was the first structural biologist to successfully demonstrate the proteolytic production of N- and C-terminal molecular halves of Lactoferrin, crystallize the C-lobe and determine the three-dimensional structure [9] [10] Her studies have established the fact that lactoferrin has a direct role in chelating the unbound non-steroidal anti-inflammatory drugs (NSAIDs) which in turn leads to the reduction in the NSAID-induced gastropathy [11].

The studies on the structure determination of Peptidoglycan Recognition Protein which is a component of the innate immune system and are conserved from insects to mammals, have given a new direction for the development of this protein as a natural protein antibiotic [12] [13]. The structural studies on the lactoperoxidase system, that is, lactoperoxidase along with its inorganic ion substrates, hydrogen peroxide, and oxidized products have given new insights into the structure-function interrelationships of this antimicrobial protein [14] [15]. Her structural studies on SPX-40 have demonstrated that the molecule acts as a protective signalling factor for breast cancer cells and have validated this protein as a drug target for breast cancer[16]. She has also been involved in the designing of inhibitors, both small organic and inorganic compounds and peptides, against these protein targets. She has successfully demonstrated the potency of these ligands in several animal models.

Prizes and Honours

Books
  • Sujata Sharma (12 September 2019). A Dragonfly's Purpose. Notion Press. ISBN 978-1-64650-765-8.
  • Sujata Sharma (16 October 2017). The Secret of the Red Crystals. Notion Press. ISBN 978-1-947988-83-5.
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See also

Notes
  1. Please see Selected bibliography section

References
  1. "On ResearchGate". On ResearchGate. 29 January 2018. Retrieved 29 January 2018.
  2. "Sujata Sharma on AIIMS". AIIMS New Delhi. 30 January 2018. Retrieved 30 January 2018.
  3. Sujata Sharma (16 October 2017). The Secret of the Red Crystals. Notion Press. pp. 11–. ISBN 978-1-947988-83-5.
  4. Sujata Sharma (12 September 2019). A Dragonfly's Purpose. Notion Press. p. 206. ISBN 978-1-64650-765-8.
  5. "Awardees of National Bioscience Awards for Career Development" (PDF). Department of Biotechnology. 2016. Retrieved 20 November 2017.
  6. "Woman Scientist Award". Biotech Research Society of India. 30 January 2018. Retrieved 30 January 2018.
  7. "National Young Woman Bioscientist Award" (PDF). Department of Biotechnology. 30 January 2018. Retrieved 30 January 2018.
  8. "Kalpana Chawla Excellence Award 2020". Tribune India. Retrieved 6 February 2020.
  9. Sharma, S.; Jasti, J.; Kumar, J.; Mohanty, A. K.; Singh, T. P. (2003). "Crystal structure of a proteolytically generated functional monoferric C-lobe of bovine lactoferrin at 1.9A resolution". Journal of Molecular Biology. 331 (2): 485–96. doi:10.1016/s0022-2836(03)00717-4. PMID 12888354.
  10. Sharma, Sujata; Sinha, Mau; Kaushik, Sanket; Kaur, Punit; Singh, Tej P. (2013). "C-lobe of lactoferrin: the whole story of the half-molecule". Biochemistry Research International. 2013: 1–8. doi:10.1155/2013/271641. PMC 3671519. PMID 23762557.
  11. Mir, Rafia; Singh, Nagendra; Vikram, Gopalakrishnapillai; Sinha, Mau; Bhushan, Asha; Kaur, Punit; Srinivasan, Alagiri; Sharma, Sujata; Singh, Tej P. (2010). "Structural and binding studies of C-terminal half (C-lobe) of lactoferrin protein with COX-2-specific non-steroidal anti-inflammatory drugs (NSAIDs)". Archives of Biochemistry and Biophysics. 500 (2): 196–202. doi:10.1016/j.abb.2010.05.026. PMID 20515646.
  12. Sharma, P.; Singh, N.; Sinha, M.; Sharma, S.; Perbandt, M.; Betzel, C.; Kaur, P.; Srinivasan, A.; Singh, T. P. (2008). "Crystal structure of the peptidoglycan recognition protein at 1.8 A resolution reveals dual strategy to combat infection through two independent functional homodimers". Journal of Molecular Biology. 378 (4): 923–32. doi:10.1016/j.jmb.2008.03.018. PMID 18395744.
  13. Sharma, P.; Dube, D.; Singh, A.; Mishra, B.; Singh, N.; Sinha, M.; Dey, S.; Kaur, P.; Mitra, D. K.; Sharma, S.; Singh, T. P. (2011). "Structural basis of recognition of pathogen-associated molecular patterns and inhibition of proinflammatory cytokines by camel peptidoglycan recognition protein". The Journal of Biological Chemistry. 286 (18): 16208–17. doi:10.1074/jbc.M111.228163. PMC 3091228. PMID 21454594.
  14. Singh, Prashant K.; Iqbal, Naseer; Sirohi, Harsh V.; Bairagya, Hridoy R.; Kaur, Punit; Sharma, Sujata; Singh, Tej P. (2018). "Structural basis of activation of mammalian heme peroxidases". Progress in Biophysics and Molecular Biology. 133: 49–55. doi:10.1016/j.pbiomolbio.2017.11.003. PMID 29174286.
  15. "Crystal structure of lactoperoxidase at 2.4 A resolution". doi:10.1016/j.jmb.2007.12.012. PMID 18191143. Cite journal requires |journal= (help)
  16. Chaudhary, A.; Kumar, V.; Singh, P. K.; Sharma, P.; Bairagya, H. R.; Kaur, P.; Sharma, S.; Chauhan, S. S.; Singh, T. P. (2018). "A glycoprotein from mammary gland secreted during involution promotes apoptosis: Structural and biological studies". Archives of Biochemistry and Biophysics. 644: 72–80. doi:10.1016/j.abb.2018.03.006. PMID 29524427.
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