Pravindra Kumar

Pravindra Kumar is an Indian biophysicist, bioinformatician, biochemist and professor at the Indian Institute of Technology Roorkee. He is known for his work on protein-protein interactions, protein engineering and structure-based drug design. The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development in 2015, one of the highest Indian science awards, for his contributions to biosciences.[1]

Pravindra Kumar
Born
India
NationalityIndian
Alma mater
Known forStudies on protein-protein interactions, protein engineering and structure-based drug design
Awards
Scientific career
Fields
Institutions

Biography
IIT Roorkee

Pravindra Kumar, after completing his master's studies at Chaudhary Charan Singh University in 1995, did his doctoral studies in biophysics at the All India Institute of Medical Sciences Delhi while working as a senior demonstrator there.[2] He earned his PhD in 2001 and proceeded to the US where he did his post doctoral studies at Purdue University.[3] Returning to India in 2005, he joined the Indian Institute of Technology Roorkee as an assistant professor and holds the position of an associate professor since 2012. At IIT Roorkee, he has held several positions such as those of associate dean (corporate interaction), chief advisor (sports), deputy chief advisor (students club) and warden.[2]

Professional profile
Coffee Flowers

Kumar focuses his interest on protein engineering and interactions as well as drug design and leads a team of researchers.[3] In 2017, his team worked on Chlorogenic acid, an aromatic compound found naturally in plants like coffea and their biochemical and structural studies using x-ray crystallography techniques revealed that the compound had anti-bacterial properties.[4] The discovery is reported to have opportunities in the development of a new class of antibiotics[5] as the compound clings to the chorismate mutase enzyme in the shikimate pathway which assists in the synthesis of aromatic amino acids and this could inhibit the growth of bacteria.[6] His studies have been documented by way of a number of articles[7][note 1] and ResearchGate, an online repository of scientific articles has listed 117 of them.[8]

Awards and honors

The Department of Biotechnology (DBT) of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards in 2015.[1]

Selected bibliography
  • Narwal, Manju; Singh, Harvijay; Pratap, Shivendra; Malik, Anjali; Kuhn, Richard J.; Kumar, Pravindra; Tomar, Shailly (2018). "Crystal structure of chikungunya virus nsP2 cysteine protease reveals a putative flexible loop blocking its active site". International Journal of Biological Macromolecules. doi:10.1016/j.ijbiomac.2018.05.007.
  • Sharma, Rajesh; Kesari, Pooja; Kumar, Pravindra; Tomar, Shailly (2018). "Structure-function insights into chikungunya virus capsid protein: Small molecules targeting capsid hydrophobic pocket". Virology. 515: 223–234. doi:10.1016/j.virol.2017.12.020.
  • Pratap, Shivendra; Dev, Aditya; Kumar, Vijay; Yadav, Ravi; Narwal, Manju; Tomar, Shailly; Kumar, Pravindra (25 July 2017). "Structure of Chorismate Mutase-like Domain of DAHPS from Bacillus subtilis Complexed with Novel Inhibitor Reveals Conformational Plasticity of Active Site". Scientific Reports. 7 (1). doi:10.1038/s41598-017-06578-1. PMC 5526877.
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See also

Notes
  1. Please see Selected bibliography section

References
  1. "Awardees of National Bioscience Awards for Career Development" (PDF). Department of Biotechnology. 2016. Retrieved 20 November 2017.
  2. Roorkee, Information Management Group, IIT (15 May 2018). "Department of Biotechnology, Indian Institute of Technology Roorkee Index". www.iitr.ac.in. Retrieved 15 May 2018.
  3. "Faculty profile" (PDF). IIT Roorkee. 15 May 2018. Retrieved 15 May 2018.
  4. "A new class of antibiotics from coffee? - Nature India". Nature India. 20 September 2017. Retrieved 15 May 2018.
  5. "IIT Roorkee discovered the antibacterial mechanism of a natural compound obtained from plant species". India Today. 23 February 2018. Retrieved 15 May 2018.
  6. "IIT-Roorkee study finds coffee compound may lead to new class of antibiotics - Times of India". The Times of India. 25 February 2018. Retrieved 15 May 2018.
  7. "On Google Scholar". Google Scholar. 15 May 2018. Retrieved 15 May 2018.
  8. "On ResearchGate". On ResearchGate. 15 May 2018. Retrieved 15 May 2018.
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