Stefanie Dimmeler

Stefanie Dimmeler (born 18 July 1967) is a German biologist specializing in the pathophysiological processes underlying cardiovascular diseases. Her awards and honours include the Gottfried Wilhelm Leibniz Prize of the German Research Foundation for her work on the programmed cell death of endothelial cells. Since 2008 she has led the Institute for Cardiovascular Regeneration at the University of Frankfurt. Her current work is focusing to develop cellular and pharmacological strategies to improve cardiovascular repair and regeneration. Her work aims to establish non-coding RNAs as novel therapeutic targets.[1]

Prof. Dr. Stefanie Dimmeler
Born (1967-07-18) 18 July 1967
Ravensburg, Germany
Alma materUniversity of Konstanz
AwardsErnst Jung Prize (2007)
Gottfried Wilhelm Leibniz Prize
Scientific career
FieldsBiology, Biochemistry
InstitutionsUniversity of Frankfurt

Life

Stefanie Dimmeler attended schools in Hagnau and Stetten and the high school in Markdorf. From 1986 to 1991 she studied biology at the University of Konstanz. In 1993 she obtained her doctorate in Konstanz on "Nitric oxide-stimulated ADP-ribosylation". From 1993 to 1995 Dimmeler was a postdoctoral fellow in the Biochemical and Experimental Division of the Department of Surgery the University of Cologne and then from 1995 to 2001 in the Medical Clinic, Department of Cardiology, the University of Frankfurt am Main. In 1998 she habilitated in the field of experimental medicine on the topic of endothelial dysfunction in atherosclerosis - studies on the apoptosis of endothelial cells. Since 2001 she has been Professor for Molecular Cardiology at the University of Frankfurt and since 2008 she is the Director of the Institute for Cardiovascular Regeneration at the Center for Molecular Medicine of the Goethe University Frankfurt. in 2005 she won the 1.55 million euro Gottfried Wilhelm Leibniz Prize.[1] Before she could receive the prize, the Deutsche Forschungsgemeinschaft ((in German) "German Research Foundation") had to clear her of all allegations of scientific misconduct, which they did on 5 July 2005.[2]

An investigation into Dimmeler's work was needed owing to mistakes in three of her publications.[2] These had been admitted and corrected, and they referred to figures used in representative examples; her conclusions were entirely sound and reproducible.[2]

Dimmeler went on to receive the Ernst Jung Prize for Medicine in 2007[3] and a 2.4 million euro research grant from the European Research Council in 2008.[4]

Since 2011 Stefanie Dimmeler is Deputy Speaker of the "German Center for Cardiovascular Research e.V." (DZHK) Location RheinMain.[5] The DZHK is a partner of the German Centers for Health Research, which are committed to improving the prevention, diagnosis and treatment of common diseases and was founded in 2011 on the initiative of the Federal Ministry of Education and Research. The goal of all six German Centers for Health Research is to bring the results of basic research into clinical application more quickly.[6]

In addition, Stefanie Dimmeler is spokeswoman for the "Cardio-Pulmonary Institute", a DFG-funded Excellence Cluster .[7]

Scientific work

Stefanie Dimmeler focuses on the molecular biology of endothelial cells, the cells lining the blood vessels. An essential aspect is apoptosis, known as programmed cell death, of the tissue. In this context, Dimmeler examines the necessary messenger substances, the development of damage to these cell structures and the possibilities of regenerating these processes. Above all, this basic research aims to provide a better understanding of the processes in arteriosclerosis and to find treatment options. It also provided initial results on stem cell therapy using bone marrow progenitor cells for the treatment of infarction patients. Current work also deals with the regulation of vascular growth and stem cells by small gene chips, so-called microRNAs.

Awards
  • 2018: Selby Travelling Fellowship of the Australian Academy of Science[8]
  • 2017: Member of the German Academy for Science Leopoldina[9]
  • 2017: Willy Pitzer Award, Bad Nauheim[10]
  • 2016: Paul Dudley White Lecture at the Scientific Session of the AHA[11]
  • 2016: Michael Oliver Memorial Lecture of the British Atherosclerosis Society
  • 2015: Thomas W. Smith Memorial Lecture Award
  • 2014-2018: Thomson Reuters "Highly Cited Researcher" 2014, 2015, 2016 and 2018
  • 2014: Madrid Award for Cardiovascular Stem Cell Therapy
  • 2010: Life Achievement Award by Dutch-German Molecular Cardiology Working Groups
  • 2008: Research Award of the GlaxoSmithKline Foundation Science4Life Award 2008
  • 2007: Ernst Jung Award for Medicine 2007
  • 2006: Karl-Landsteiner Lecture, German Association for Transfusion Medicine & Immunhematology
  • 2006: Basic Science Lecture and Silver Medal of the European Society of Cardiology
  • 2006: FEBS Anniversary Prize 2006
  • 2005: George E. Brown Memorial Lecture at the Scientific Session of the AHA
  • 2005: Leibniz Award of the Deutsche Forschungsgemeinschaft (DFG)
  • 2004: Forssmann Award 2004
  • 2002: Alfried Krupp-Award 2002
  • 2000: Award of the German Cardiac Society (Fraenkel-Preis)
  • 1999: Award of the Herbert and Hedwig Eckelmann-Foundation
  • 1998: Award of the German Heart Foundation
  • 1994: Fritz-Külz-Award of the German Association of Pharmacology and Toxicology
  • 1991: Foundation of German Sciences, Award
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References
  1. Stefanie Dimmeler, Lifeboat Foundation, retrieved 28 May 2010.
  2. Stefanie Dimmeler cleared, Medical News Today, published 12 July 2005, retrieved 28 May 2010.
  3. Boehringer Ingelheim Fonds Archived 2010-02-10 at the Wayback Machine, Foundation for Basic Research in Medicine, retrieved 28 May 2010
  4. Promoting the healing process after a heart attack, Eurekalert, published 28 October 2008, retrieved 28 May 2010.
  5. "RheinMain: DZHK". dzhk.de. Retrieved 2019-09-18.
  6. BMBF-Internetredaktion. "Deutsche Zentren der Gesundheitsforschung - BMBF". Bundesministerium für Bildung und Forschung - BMBF (in German). Retrieved 2019-09-18.
  7. "DFG - EXS 2026: Cardio-Pulmonary Institute (CPI)". www.dfg.de (in German). Retrieved 2019-09-18.
  8. "Academy awards travelling fellowships to international researchers | Australian Academy of Science". www.science.org.au. Retrieved 2019-09-18.
  9. "Mitglieder". www.leopoldina.org (in German). Retrieved 2019-09-18.
  10. "25 000-Euro-Preis für Frankfurter Forscherin". Frankfurter Neue Presse (in German). 2017-06-28. Retrieved 2019-09-18.
  11. Sellke Frank W.; Peterson Eric D. (2017-01-03). "Highlights of the American Heart Association Scientific Sessions 2016". Circulation. 135 (1): 100–101. doi:10.1161/CIRCULATIONAHA.116.026548. PMID 28028063.
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