Specific granule

Specific granules are secretory vesicles found exclusively in cells of the immune system called granulocytes.

It is sometimes described as applying specifically to neutrophils,[1] and sometimes the term is applied to other types of cells.[2]

These granules store a mixture of cytotoxic molecules, including many enzymes and antimicrobial peptides, that are released by a process called degranulation following activation of the granulocyte by an immune stimulus.

Specific granules are also known as "secondary granules".[3]

Contents

Examples of cytotoxic molecule stored by specific granules in different granulocytes include:

Clinical significance

A specific granule deficiency can be associated with CEBPE.[4]

gollark: I am not going down the path of audiophiles, where I have to spend significant amounts of money for marginal audio quality gains which I'll then just get used to anyway.
gollark: no.
gollark: Me too, except I'd probably just listen off my laptop and generic cheap headphones because I don't really care.
gollark: They probably make them from digital recordings anyway.
gollark: Vinyl is analog, it's *inherently* lossy.

References
  1. "Definition: specific granule from Online Medical Dictionary".
  2. Okuda M, Takenaka T, Kawabori S, Ogami Y (July 1981). "Ultrastructural study of the specific granule of the human eosinophil". J. Submicrosc. Cytol. 13 (3): 465–71. PMID 7334549.
  3. John P. Greer; Maxwell Myer Wintrobe (1 December 2008). Wintrobe's clinical hematology. Lippincott Williams & Wilkins. pp. 173–. ISBN 978-0-7817-6507-7. Retrieved 10 November 2010.
  4. Online Mendelian Inheritance in Man (OMIM): SPECIFIC GRANULE DEFICIENCY; SGD - 245480


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