SOCS7

Suppressor of cytokine signaling 7 is a protein that in humans is encoded by the SOCS7 gene.[5][6][7]

SOCS7
Identifiers
Aliases	SOCS7, NAP4, NCKAP4, suppressor of cytokine signaling 7
External IDs	OMIM: 608788 MGI: 2651588 HomoloGene: 16331 GeneCards: SOCS7
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 38,351,844 bp[1] End 38,405,593 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 97,362,435 bp[2] End 97,398,542 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • SH3 domain binding • protein kinase inhibitor activity • GO:0001948 protein binding • 1-phosphatidylinositol-3-kinase regulator activity Cellular component • cell membrane • membrane • cell nucleus • cytoplasm • cytosol • phosphatidylinositol 3-kinase complex Biological process • insulin receptor signaling pathway • regulation of growth • negative regulation of signal transduction • GO:0007243 intracellular signal transduction • cerebral cortex radially oriented cell migration • layer formation in cerebral cortex • fat cell differentiation • protein ubiquitination • negative regulation of protein kinase activity • cytokine-mediated signaling pathway • radial glia guided migration of Purkinje cell • negative regulation of JAK-STAT cascade • biological process • regulation of phosphatidylinositol 3-kinase activity • phosphatidylinositol phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	30837	192157
Ensembl	ENSG00000274229 ENSG00000274211	ENSMUSG00000038485
UniProt	O14512	Q8VHQ2
RefSeq (mRNA)	NM_014598	NM_138657
RefSeq (protein)	NP_055413	NP_619598
Location (UCSC)	Chr 17: 38.35 – 38.41 Mb	Chr 11: 97.36 – 97.4 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Model organisms

Socs7 knockout mouse phenotype

Characteristic	Phenotype
Homozygote viability	Normal
Fertility	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Abnormal[8]
Eye morphology	Normal
Clinical chemistry	Normal
Haematology	Normal
Peripheral blood lymphocytes	Normal
Micronucleus test	Normal
Heart weight	Normal
Tail epidermis wholemount	Normal
Skin Histopathology	Normal
Brain histopathology	Normal
Salmonella infection	Normal[9]
Citrobacter infection	Normal[10]
All tests and analysis from[11][12]

Model organisms have been used in the study of SOCS7 function. A conditional knockout mouse line, called Socs7^{tm1a(EUCOMM)Wtsi}[13][14] was generated as part of the International Knockout Mouse Consortium program—a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[15][16][17]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[11][18] Twenty five tests were carried out on mutant mice and one significant abnormality was observed: homozygous mutant males showed a decreased response to stress-induced hyperthermia.[11]

Interactions

SOCS7 has been shown to interact with NCK1.[5]

References

1. ENSG00000274211 GRCh38: Ensembl release 89: ENSG00000274229, ENSG00000274211 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038485 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Matuoka K, Miki H, Takahashi K, Takenawa T (Oct 1997). "A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs". Biochemical and Biophysical Research Communications. 239 (2): 488–92. doi:10.1006/bbrc.1997.7492. PMID 9344857.
6. Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (May 2002). "The SOCS box: a tale of destruction and degradation". Trends in Biochemical Sciences. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
7. "Entrez Gene: SOCS7 suppressor of cytokine signaling 7".
8. "Body temperature data for Socs7". Wellcome Trust Sanger Institute.
9. "Salmonella infection data for Socs7". Wellcome Trust Sanger Institute.
10. "Citrobacter infection data for Socs7". Wellcome Trust Sanger Institute.
11. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
12. Mouse Resources Portal, Wellcome Trust Sanger Institute.
13. "International Knockout Mouse Consortium".
14. "Mouse Genome Informatics".
15. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
16. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
17. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
18. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading

• Cooney RN (Feb 2002). "Suppressors of cytokine signaling (SOCS): inhibitors of the JAK/STAT pathway". Shock. 17 (2): 83–90. doi:10.1097/00024382-200202000-00001. PMID 11837794.
• Wormald S, Hilton DJ (Jan 2004). "Inhibitors of cytokine signal transduction" (PDF). The Journal of Biological Chemistry. 279 (2): 821–4. doi:10.1074/jbc.R300030200. PMID 14607831.
• Fujimoto M, Naka T (Dec 2003). "Regulation of cytokine signaling by SOCS family molecules". Trends in Immunology. 24 (12): 659–66. doi:10.1016/j.it.2003.10.008. PMID 14644140.
• Hilton DJ, Richardson RT, Alexander WS, Viney EM, Willson TA, Sprigg NS, Starr R, Nicholson SE, Metcalf D, Nicola NA (Jan 1998). "Twenty proteins containing a C-terminal SOCS box form five structural classes". Proceedings of the National Academy of Sciences of the United States of America. 95 (1): 114–9. doi:10.1073/pnas.95.1.114. PMC 18144. PMID 9419338.
• Dogusan Z, Hooghe-Peters EL, Berus D, Velkeniers B, Hooghe R (Sep 2000). "Expression of SOCS genes in normal and leukemic human leukocytes stimulated by prolactin, growth hormone and cytokines". Journal of Neuroimmunology. 109 (1): 34–9. doi:10.1016/S0165-5728(00)00300-3. PMID 10969179.
• Krebs DL, Uren RT, Metcalf D, Rakar S, Zhang JG, Starr R, De Souza DP, Hanzinikolas K, Eyles J, Connolly LM, Simpson RJ, Nicola NA, Nicholson SE, Baca M, Hilton DJ, Alexander WS (Jul 2002). "SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation". Molecular and Cellular Biology. 22 (13): 4567–78. doi:10.1128/MCB.22.13.4567-4578.2002. PMC 133908. PMID 12052866.
• Martens N, Wery M, Wang P, Braet F, Gertler A, Hooghe R, Vandenhaute J, Hooghe-Peters EL (Aug 2004). "The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin". Experimental Cell Research. 298 (1): 239–48. doi:10.1016/j.yexcr.2004.04.002. PMID 15242778.
• Martens N, Uzan G, Wery M, Hooghe R, Hooghe-Peters EL, Gertler A (Apr 2005). "Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation". The Journal of Biological Chemistry. 280 (14): 13817–23. doi:10.1074/jbc.M411596200. PMID 15677474.
• Banks AS, Li J, McKeag L, Hribal ML, Kashiwada M, Accili D, Rothman PB (Sep 2005). "Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans". The Journal of Clinical Investigation. 115 (9): 2462–71. doi:10.1172/JCI23853. PMC 1190369. PMID 16127460.
• Kremer BE, Adang LA, Macara IG (Sep 2007). "Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7". Cell. 130 (5): 837–50. doi:10.1016/j.cell.2007.06.053. PMC 2085444. PMID 17803907.