SNRPA1

U2 small nuclear ribonucleoprotein A' is a protein that in humans is encoded by the SNRPA1 gene.[5][6]

SNRPA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A9N
Identifiers
Aliases	SNRPA1, Lea1, small nuclear ribonucleoprotein polypeptide A', U2A'
External IDs	OMIM: 603521 MGI: 1916231 HomoloGene: 2325 GeneCards: SNRPA1
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q26.3 Start 101,281,510 bp[1] End 101,295,282 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 C Start 66,059,003 bp[2] End 66,074,587 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • U2 snRNA binding • GO:0001948 protein binding • RNA binding Cellular component • catalytic step 2 spliceosome • spliceosomal complex • small nuclear ribonucleoprotein complex • cell nucleus • U2 snRNP • nucleoplasm • nuclear speck • nuclear body • U2-type precatalytic spliceosome • U2-type catalytic step 2 spliceosome • Nucleocapsid Biological process • mRNA splicing, via spliceosome • mRNA processing • RNA splicing • interleukin-12-mediated signaling pathway • spermatogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6627	68981
Ensembl	ENSG00000131876	ENSMUSG00000030512
UniProt	P09661	P57784
RefSeq (mRNA)	NM_003090	NM_021336
RefSeq (protein)	NP_003081	NP_067311
Location (UCSC)	Chr 15: 101.28 – 101.3 Mb	Chr 7: 66.06 – 66.07 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SNRPA1 has been shown to interact with CDC5L.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000131876 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030512 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sillekens PT, Beijer RP, Habets WJ, van Verooij WJ (March 1989). "Molecular cloning of the cDNA for the human U2 snRNA-specific A' protein". Nucleic Acids Research. 17 (5): 1893–906. doi:10.1093/nar/17.5.1893. PMC 317531. PMID 2928112.
6. "Entrez Gene: SNRPA1 small nuclear ribonucleoprotein polypeptide A'".
7. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

Further reading

• Ohno M, Kataoka N, Shimura Y (December 1990). "A nuclear cap binding protein from HeLa cells". Nucleic Acids Research. 18 (23): 6989–95. doi:10.1093/nar/18.23.6989. PMC 332760. PMID 2148205.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Kjems J, Sharp PA (August 1993). "The basic domain of Rev from human immunodeficiency virus type 1 specifically blocks the entry of U4/U6.U5 small nuclear ribonucleoprotein in spliceosome assembly". Journal of Virology. 67 (8): 4769–76. PMC 237863. PMID 8331728.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Blencowe BJ, Issner R, Nickerson JA, Sharp PA (April 1998). "A coactivator of pre-mRNA splicing". Genes & Development. 12 (7): 996–1009. doi:10.1101/gad.12.7.996. PMC 316672. PMID 9531537.
• Price SR, Evans PR, Nagai K (August 1998). "Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA". Nature. 394 (6694): 645–50. Bibcode:1998Natur.394..645P. doi:10.1038/29234. PMID 9716128.
• Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, et al. (September 1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nature Genetics. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
• Eldridge AG, Li Y, Sharp PA, Blencowe BJ (May 1999). "The SRm160/300 splicing coactivator is required for exon-enhancer function". Proceedings of the National Academy of Sciences of the United States of America. 96 (11): 6125–30. Bibcode:1999PNAS...96.6125E. doi:10.1073/pnas.96.11.6125. PMC 26846. PMID 10339552.
• Lundin M, Mikkelsen B, Gudim M, Syed M (March 2000). "Gene Structure of the U2 snRNP-Specific A' Protein Gene from Salmo salar: Alternative Transcripts Observed". Marine Biotechnology. 2 (2): 204–211. doi:10.1007/s101269900015. PMID 10811961.
• Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation". Nature. 414 (6866): 929–33. doi:10.1038/414929a. PMID 11780068.
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, et al. (January 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
• Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (April 2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.