Small nuclear ribonucleoprotein polypeptide A

U1 small nuclear ribonucleoprotein A is a protein that in humans is encoded by the SNRPA gene.[3][4]

SNRPA
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1AUD, 1DRZ, 1DZ5, 1FHT, 1M5K, 1M5O, 1M5P, 1M5V, 1NU4, 1OIA, 1SJ3, 1SJ4, 1SJF, 1U6B, 1URN, 1VBX, 1VBY, 1VBZ, 1VC0, 1VC5, 1VC6, 1ZZN, 2A3J, 2NZ4, 2OIH, 2OJ3, 2U1A, 3BO2, 3BO3, 3BO4, 3CUL, 3CUN, 3EGZ, 3G8S, 3G8T, 3G96, 3G9C, 3HHN, 3IIN, 3IRW, 3IWN, 3K0J, 3L3C, 3MUM, 3MUR, 3MUT, 3MUV, 3MXH, 3P49, 3PGW, 3R1H, 3R1L, 3UCU, 3UCZ, 3UD3, 3UD4, 4C4W, 4PR6, 4PRF, 4W90, 4YB1, 5DDO, 5DDR, 5DDQ, 5DDP, 5FJ4
Identifiers
Aliases	SNRPA, Mud1, U1-A, U1A, Small nuclear ribonucleoprotein polypeptide A
External IDs	OMIM: 182285 HomoloGene: 3380 GeneCards: SNRPA
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 40,750,637 bp[1] End 40,765,389 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • U1 snRNA binding • snRNA stem-loop binding • GO:0001948 protein binding • RNA binding • nucleic acid binding • U1 snRNP binding • identical protein binding Cellular component • spliceosomal complex • cell nucleus • nucleoplasm • U1 snRNP Biological process • mRNA processing • regulation of mRNA polyadenylation • RNA splicing • mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6626	n/a
Ensembl	ENSG00000077312	n/a
UniProt	P09012	n/a
RefSeq (mRNA)	NM_004596	n/a
RefSeq (protein)	NP_004587	n/a
Location (UCSC)	Chr 19: 40.75 – 40.77 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Interactions

Small nuclear ribonucleoprotein polypeptide A has been shown to interact with CDC5L.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000077312 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Schonk D, van Dijk P, Riegmann P, Trapman J, Holm C, Willcocks TC, Sillekens P, van Venrooij W, Wimmer E, Geurts van Kessel A (January 1991). "Assignment of seven genes to distinct intervals on the midportion of human chromosome 19q surrounding the myotonic dystrophy gene region". Cytogenetics and Cell Genetics. 54 (1–2): 15–9. doi:10.1159/000132946. PMID 1701111.
4. "Entrez Gene: SNRPA small nuclear ribonucleoprotein polypeptide A".
5. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

Further reading

• Hoffman DW, Query CC, Golden BL, White SW, Keene JD (March 1991). "RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins". Proceedings of the National Academy of Sciences of the United States of America. 88 (6): 2495–9. Bibcode:1991PNAS...88.2495H. doi:10.1073/pnas.88.6.2495. PMC 51259. PMID 1826055.
• Nelissen RL, Sillekens PT, Beijer RP, Geurts van Kessel AH, van Venrooij WJ (June 1991). "Structure, chromosomal localization and evolutionary conservation of the gene encoding human U1 snRNP-specific A protein". Gene. 102 (2): 189–96. doi:10.1016/0378-1119(91)90077-O. PMID 1831431.
• Jessen TH, Oubridge C, Teo CH, Pritchard C, Nagai K (November 1991). "Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA". The EMBO Journal. 10 (11): 3447–56. doi:10.1002/j.1460-2075.1991.tb04909.x. PMC 453073. PMID 1833186.
• Nagai K, Oubridge C, Jessen TH, Li J, Evans PR (December 1990). "Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A". Nature. 348 (6301): 515–20. Bibcode:1990Natur.348..515N. doi:10.1038/348515a0. PMID 2147232.
• Sillekens PT, Habets WJ, Beijer RP, van Venrooij WJ (December 1987). "cDNA cloning of the human U1 snRNA-associated A protein: extensive homology between U1 and U2 snRNP-specific proteins". The EMBO Journal. 6 (12): 3841–8. doi:10.1002/j.1460-2075.1987.tb02721.x. PMC 553857. PMID 2962859.
• Oubridge C, Ito N, Evans PR, Teo CH, Nagai K (December 1994). "Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin". Nature. 372 (6505): 432–8. Bibcode:1994Natur.372..432O. doi:10.1038/372432a0. PMID 7984237.
• Howe PW, Nagai K, Neuhaus D, Varani G (August 1994). "NMR studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein". The EMBO Journal. 13 (16): 3873–81. doi:10.1002/j.1460-2075.1994.tb06698.x. PMC 395300. PMID 8070414.
• Allain FH, Gubser CC, Howe PW, Nagai K, Neuhaus D, Varani G (April 1996). "Specificity of ribonucleoprotein interaction determined by RNA folding during complex formulation". Nature. 380 (6575): 646–50. Bibcode:1996Natur.380..646A. doi:10.1038/380646a0. PMID 8602269.
• Avis JM, Allain FH, Howe PW, Varani G, Nagai K, Neuhaus D (March 1996). "Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding". Journal of Molecular Biology. 257 (2): 398–411. doi:10.1006/jmbi.1996.0171. PMID 8609632.
• Lu J, Hall KB (August 1997). "Tertiary structure of RBD2 and backbone dynamics of RBD1 and RBD2 of the human U1A protein determined by NMR spectroscopy". Biochemistry. 36 (34): 10393–405. doi:10.1021/bi9709811. PMID 9265619.
• Allain FH, Howe PW, Neuhaus D, Varani G (September 1997). "Structural basis of the RNA-binding specificity of human U1A protein". The EMBO Journal. 16 (18): 5764–72. doi:10.1093/emboj/16.18.5764. PMC 1170207. PMID 9312034.
• Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M (September 1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nature Genetics. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
• Ferré-D'Amaré AR, Zhou K, Doudna JA (October 1998). "Crystal structure of a hepatitis delta virus ribozyme". Nature. 395 (6702): 567–74. Bibcode:1998Natur.395..567F. doi:10.1038/26912. PMID 9783582.
• Lutz CS, Cooke C, O'Connor JP, Kobayashi R, Alwine JC (December 1998). "The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor". RNA. 4 (12): 1493–9. doi:10.1017/S1355838298981183. PMC 1369720. PMID 9848648.
• Hetzer M, Mattaj IW (January 2000). "An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B" spliceosome proteins". The Journal of Cell Biology. 148 (2): 293–303. doi:10.1083/jcb.148.2.293. PMC 2174293. PMID 10648562.
• Klein Gunnewiek JM, Hussein RI, van Aarssen Y, Palacios D, de Jong R, van Venrooij WJ, Gunderson SI (March 2000). "Fourteen residues of the U1 snRNP-specific U1A protein are required for homodimerization, cooperative RNA binding, and inhibition of polyadenylation". Molecular and Cellular Biology. 20 (6): 2209–17. doi:10.1128/MCB.20.6.2209-2217.2000. PMC 110837. PMID 10688667.
• Varani L, Gunderson SI, Mattaj IW, Kay LE, Neuhaus D, Varani G (April 2000). "The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein". Nature Structural Biology. 7 (4): 329–35. doi:10.1038/74101. PMID 10742179.
• Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
• Simmons A, Aluvihare V, McMichael A (June 2001). "Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators". Immunity. 14 (6): 763–77. doi:10.1016/S1074-7613(01)00158-3. PMID 11420046.