SNAPC1

snRNA-activating protein complex subunit 1 is a protein that in humans is encoded by the SNAPC1 gene.[5][6]

SNAPC1
Identifiers
Aliases	SNAPC1, PTFgamma, SNAP43, small nuclear RNA activating complex polypeptide 1
External IDs	OMIM: 600591 MGI: 1922877 HomoloGene: 2317 GeneCards: SNAPC1
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q23.2 Start 61,762,420 bp[1] End 61,796,428 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C3 Start 73,964,481 bp[2] End 73,988,966 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding Cellular component • snRNA-activating protein complex • cell nucleus • nucleoplasm • nucleolus Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • snRNA transcription from RNA polymerase III promoter • snRNA transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6617	75627
Ensembl	ENSG00000023608	ENSMUSG00000021113
UniProt	Q16533	Q8K0S9
RefSeq (mRNA)	NM_003082	NM_178392
RefSeq (protein)	NP_003073	NP_848479
Location (UCSC)	Chr 14: 61.76 – 61.8 Mb	Chr 12: 73.96 – 73.99 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SNAPC1 has been shown to interact with SNAPC4,[7] SNAPC3[7][8] and Retinoblastoma protein.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000023608 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021113 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Maeng JH; Yoon JB (September 1998). "The human PTFgamma/SNAP43 gene: structure, chromosomal location, and identification of a VNTR in 5'-UTR". J Biochem. 124 (1): 23–7. doi:10.1093/oxfordjournals.jbchem.a022085. PMID 9644240.
6. "Entrez Gene: SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa".
7. Ma, B; Hernandez N (February 2001). "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc". J. Biol. Chem. United States. 276 (7): 5027–35. doi:10.1074/jbc.M009301200. ISSN 0021-9258. PMID 11056176.
8. Henry, R W; Ma B; Sadowski C L; Kobayashi R; Hernandez N (Dec 1996). "Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc". EMBO J. ENGLAND. 15 (24): 7129–36. ISSN 0261-4189. PMC 452539. PMID 9003788.
9. Hirsch, H A; Gu L; Henry R W (Dec 2000). "The Retinoblastoma Tumor Suppressor Protein Targets Distinct General Transcription Factors To Regulate RNA Polymerase III Gene Expression". Mol. Cell. Biol. UNITED STATES. 20 (24): 9182–91. doi:10.1128/MCB.20.24.9182-9191.2000. ISSN 0270-7306. PMC 102176. PMID 11094070.

Further reading

• Henry RW; Sadowski CL; Kobayashi R; Hernandez N (1995). "A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III". Nature. 374 (6523): 653–6. Bibcode:1995Natur.374..653H. doi:10.1038/374653a0. PMID 7715707.
• Yoon JB; Roeder RG (1996). "Cloning of two proximal sequence element-binding transcription factor subunits (gamma and delta) that are required for transcription of small nuclear RNA genes by RNA polymerases II and III and interact with the TATA-binding protein". Mol. Cell. Biol. Advances in Molecular and Cell Biology. 16 (1): 1–9. doi:10.1016/S1569-2558(08)60061-2. ISBN 978-0-7623-0143-0. PMC 230972. PMID 8524284.
• Henry RW, Ma B, Sadowski CL, et al. (1997). "Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc". EMBO J. 15 (24): 7129–36. PMC 452539. PMID 9003788.
• Ma B; Hernandez N (2001). "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc". J. Biol. Chem. 276 (7): 5027–35. doi:10.1074/jbc.M009301200. PMID 11056176.
• Hirsch HA; Gu L; Henry RW (2001). "The Retinoblastoma Tumor Suppressor Protein Targets Distinct General Transcription Factors To Regulate RNA Polymerase III Gene Expression". Mol. Cell. Biol. 20 (24): 9182–91. doi:10.1128/MCB.20.24.9182-9191.2000. PMC 102176. PMID 11094070.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hinkley CS, Hirsch HA, Gu L, et al. (2003). "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition". J. Biol. Chem. 278 (20): 18649–57. doi:10.1074/jbc.M204247200. PMID 12621023.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gu L; Esselman WJ; Henry RW (2005). "Cooperation between small nuclear RNA-activating protein complex (SNAPC) and TATA-box-binding protein antagonizes protein kinase CK2 inhibition of DNA binding by SNAPC". J. Biol. Chem. 280 (30): 27697–704. doi:10.1074/jbc.M503206200. PMID 15955816.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.