SNAPC3

snRNA-activating protein complex subunit 3 is a protein that in humans is encoded by the SNAPC3 gene.[5][6]

SNAPC3
Identifiers
Aliases	SNAPC3, PTFbeta, SNAP50, small nuclear RNA activating complex polypeptide 3
External IDs	OMIM: 602348 MGI: 1916338 HomoloGene: 31130 GeneCards: SNAPC3
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p22.3 Start 15,422,704 bp[1] End 15,465,953 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C3 Start 83,417,724 bp[2] End 83,467,676 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • DNA binding Cellular component • cell nucleus • nucleoplasm • nucleolus • nuclear body Biological process • snRNA transcription • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • transcription, DNA-templated • transcription from RNA polymerase III promoter • snRNA transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6619	77634
Ensembl	ENSG00000164975	ENSMUSG00000028483
UniProt	Q92966	Q9D2C9
RefSeq (mRNA)	NM_001039697 NM_003084	NM_029949 NM_001358795
RefSeq (protein)	NP_001034786 NP_001356576 NP_001356577 NP_001356578 NP_001356579 NP_001356580	NP_084225 NP_001345724
Location (UCSC)	Chr 9: 15.42 – 15.47 Mb	Chr 4: 83.42 – 83.47 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SNAPC3 has been shown to interact with SNAPC1[5][7] and retinoblastoma protein.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000164975 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028483 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Henry RW, Ma B, Sadowski CL, Kobayashi R, Hernandez N (December 1996). "Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc". The EMBO Journal. 15 (24): 7129–36. doi:10.1002/j.1460-2075.1996.tb01104.x. PMC 452539. PMID 9003788.
6. "Entrez Gene: SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa".
7. Ma B, Hernandez N (February 2001). "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc". The Journal of Biological Chemistry. 276 (7): 5027–35. doi:10.1074/jbc.M009301200. PMID 11056176.
8. Hirsch HA, Gu L, Henry RW (December 2000). "The retinoblastoma tumor suppressor protein targets distinct general transcription factors to regulate RNA polymerase III gene expression". Molecular and Cellular Biology. 20 (24): 9182–91. doi:10.1128/MCB.20.24.9182-9191.2000. PMC 102176. PMID 11094070.

Further reading

• Bagramian ER, Bogdanova EA, Krymskaia ML, Sokovykh SI (February 1977). "[Diagnostic importance of determining 17-ketosteroids in gynecology]". Akusherstvo I Ginekologiia (2): 65–7. PMID 900378.
• Henry RW, Sadowski CL, Kobayashi R, Hernandez N (April 1995). "A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III". Nature. 374 (6523): 653–6. Bibcode:1995Natur.374..653H. doi:10.1038/374653a0. PMID 7715707.
• Bai L, Wang Z, Yoon JB, Roeder RG (October 1996). "Cloning and characterization of the beta subunit of human proximal sequence element-binding transcription factor and its involvement in transcription of small nuclear RNA genes by RNA polymerases II and III". Molecular and Cellular Biology. 16 (10): 5419–26. doi:10.1128/mcb.16.10.5419. PMC 231541. PMID 8816454.
• Ma B, Hernandez N (February 2001). "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc". The Journal of Biological Chemistry. 276 (7): 5027–35. doi:10.1074/jbc.M009301200. PMID 11056176.
• Hirsch HA, Gu L, Henry RW (December 2000). "The retinoblastoma tumor suppressor protein targets distinct general transcription factors to regulate RNA polymerase III gene expression". Molecular and Cellular Biology. 20 (24): 9182–91. doi:10.1128/MCB.20.24.9182-9191.2000. PMC 102176. PMID 11094070.
• Hinkley CS, Hirsch HA, Gu L, LaMere B, Henry RW (May 2003). "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition". The Journal of Biological Chemistry. 278 (20): 18649–57. doi:10.1074/jbc.M204247200. PMID 12621023.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
• Jawdekar GW, Hanzlowsky A, Hovde SL, Jelencic B, Feig M, Geiger JH, Henry RW (October 2006). "The unorthodox SNAP50 zinc finger domain contributes to cooperative promoter recognition by human SNAPC". The Journal of Biological Chemistry. 281 (41): 31050–60. doi:10.1074/jbc.M603810200. PMID 16901896.