Renal compensation

Renal compensation is a mechanism by which the kidneys can regulate the plasma pH. It is slower than respiratory compensation, but has a greater ability to restore normal values.

In respiratory acidosis, the kidney produces and excretes ammonium (NH₄⁺) and monophosphate, generating bicarbonate in the process while clearing acid.[1]

In respiratory alkalosis, less bicarbonate (HCO₃⁻) is reabsorbed, thus lowering the pH.[2]

References

Nosek, Thomas M. "Section 7/7ch12/7ch12p45". Essentials of Human Physiology. Archived from the original on 2016-03-24.
Nosek, Thomas M. "Section 7/7ch12/7ch12p48". Essentials of Human Physiology. Archived from the original on 2016-03-24.

Physiology of the kidneys and acid–base physiology

Creating urine

Secretion	clearance Pharmacokinetics Clearance of medications Urine flow rate
Reabsorption	Solvent drag sodium chloride urea glucose oligopeptides protein
Filtration	Renal blood flow Ultrafiltration Countercurrent exchange Filtration fraction

Other functions

Hormones	Antidiuretic hormone Aldosterone Atrial natriuretic peptide Renin Erythropoietin Calcitriol Prostaglandins
Fluid balance	Body water: Intracellular fluid/Cytosol Extracellular fluid (Interstitial fluid Plasma Transcellular fluid)
Acid–base balance	Fluid balance Darrow Yannet diagram Base excess Davenport diagram Anion gap (Delta ratio) Arterial blood gas test Winters' formula Buffering Bicarbonate buffer system Respiratory compensation Renal compensation

Assessment and measurement

Glomerular filtration rate
Creatinine clearance
Augmented renal clearance
Renal clearance ratio
Urea reduction ratio
Kt/V
Standardized Kt/V
Dialysis adequacy
- Hemodialysis product
PAH clearance (Effective renal plasma flow
Extraction ratio)

Other

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