Proton therapy

In the field of medical treatment, proton therapy, or proton radiotherapy, is a type of particle therapy that uses a beam of protons to irradiate diseased tissue, most often to treat cancer. The chief advantage of proton therapy over other types of external beam radiotherapy (e.g., radiation therapy, or photon therapy) is that the dose of protons is deposited over a narrow range of depth, which results in minimal entry, exit, or scattered radiation dose to healthy nearby tissues.

Proton therapy
Proton therapy equipment at the Mayo Clinic in Rochester, Minnesota
Other namesproton beam therapy
ICD-10-PCSZ92.3

When evaluating whether to treat a tumor with photon or proton therapy, physicians may choose proton therapy if it is important to deliver a higher radiation dose to targeted tissues while significantly decreasing radiation to nearby organs at risk. [1] The American Society for Radiation Oncology Model Policy for Proton Beam therapy states that proton therapy is considered reasonable in instances where sparing the surrounding normal tissue “cannot be adequately achieved with photon-based radiotherapy” and can benefit the patient. Like photon radiation therapy, proton therapy is often used in conjunction with surgery and/or chemotherapy to most effectively treat cancer.

Description
Main article: Radiation therapy § Mechanism of action
In a typical treatment plan for proton therapy, the spread out Bragg peak (SOBP, dashed blue line) shows how the radiation is distributed. The SOBP is the sum of several individual Bragg peaks (thin blue lines) at staggered depths. Note that the vast majority of the proton radiation is delivered to the tumor, not to the skin and shallow tissues in front of the tumor or to the deep tissues behind the tumor. The red line shows the depth-dose plot of an X-ray beam (photon or conventional radiation therapy) for comparison. The pink area represents additional doses of X-ray radiotherapy in front and behind the tumor – which can damage normal tissues and cause secondary cancers, especially of the skin.[2]

Proton therapy is a type of external beam radiotherapy that uses ionizing radiation. In proton therapy, medical personnel use a particle accelerator to target a tumor with a beam of protons.[3][4] These charged particles damage the DNA of cells, ultimately killing them by stopping their reproduction and thereby eliminating the tumor. Cancerous cells are particularly vulnerable to attacks on DNA because of their high rate of division and their limited abilities to repair DNA damage. Some cancers with specific defects in DNA repair may be more sensitive to proton radiation.[5]

Proton therapy offers physicians the “superb ability” to deliver a highly conformal beam, i.e., delivering radiation that conforms to the shape and depth of the tumor and completely sparing much of the surrounding, normal tissue.[6] For example, when comparing proton therapy to the most advanced types of photon therapy—intensity-modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT)—proton therapy can deliver similar or higher radiation doses to the tumor with a 50%-60% lower total body radiation dose. [7] [1]

Protons have the ability to focus energy delivery to conform to the tumor shape, delivering only low-dose radiation to surrounding tissue. As a result, the patient can experience fewer side effects. All protons of a given energy have a certain penetration range; very few protons penetrate beyond that distance.[8] Furthermore, the dose delivered to tissue is maximized only over the last few millimeters of the particle's range; this maximum is called the spread out Bragg peak, often referred to as the SOBP (see visual).[9]

To treat tumors at greater depths, the proton accelerator must produce a beam with higher energy, typically given in eV (electron volts). Accelerators used for proton therapy typically produce protons with energies in the range of 70 to 250 MeV. Adjusting proton energy during the treatment maximizes the cell damage the proton beam causes within the tumor. Tissue closer to the surface of the body than the tumor receives reduced radiation, and therefore reduced damage. Tissues deeper in the body receive very few protons, so the dosage becomes immeasurably small.[8]

In most treatments, protons of different energies with Bragg peaks at different depths are applied to treat the entire tumor. These Bragg peaks are shown as thin blue lines in the figure in this section. It is important to understand that, while tissues behind (or deeper than) the tumor receive almost no radiation from proton therapy, the tissues in front of (shallower than) the tumor receive radiation dosage based on the SOBP.

Equipment

Most installed proton therapy systems utilise isochronous cyclotrons.[10][11] Cyclotrons are considered simple to operate, reliable and can be made compact, especially with the use of superconducting magnets.[12] Synchrotrons can also be used, with the advantage of easier production at varying energies.[13] Linear accelerators, as used for photon radiation therapy, are becoming commercially available as limitations of size and cost are resolved.[14] Modern proton systems incorporate: high-quality imaging for daily assessment of tumor contours; treatment planning software illustrating 3D dose distributions; and various system configurations, e.g., multiple treatment rooms connected to one accelerator. Partly because of these advancements in technology, and partly because of the continually increasing amount of proton clinical data, the number of hospitals offering proton therapy continues to increase.

FLASH radiotherapy is a technique under development for photon and proton treatments, utilising very high dose rates (necessitating large beam currents). If applied clinically, it could shorten treatment time to just 1–3, 1 second sessions, while further reducing side effects.[15][16][17]

History

The first suggestion that energetic protons could be an effective treatment method was made by Robert R. Wilson[18] in a paper published in 1946 while he was involved in the design of the Harvard Cyclotron Laboratory (HCL).[19] The first treatments were performed with particle accelerators built for physics research, notably Berkeley Radiation Laboratory in 1954 and at Uppsala in Sweden in 1957. In 1961, a collaboration began between HCL and the Massachusetts General Hospital (MGH) to pursue proton therapy. Over the next 41 years, this program refined and expanded these techniques while treating 9,116 patients[20] before the cyclotron was shut down in 2002. The ITEP center in Moscow, which began treating patients in 1969, is the oldest proton center still in operation. The Paul Scherrer Institute in Switzerland was the world’s first proton center to treat ocular tumors beginning in 1984. In addition, they invented pencil beam scanning in 1996, which is now the state-of-the art form of proton therapy.

The world's first hospital-based proton therapy center was a low energy cyclotron centre for ocular tumours at the Clatterbridge Centre for Oncology in the UK, opened in 1989,[21] followed in 1990 at the Loma Linda University Medical Center (LLUMC) in Loma Linda, California. Later, the Northeast Proton Therapy Center at Massachusetts General Hospital was brought online, and the HCL treatment program was transferred to it during 2001 and 2002. By 2010 these facilities were joined by an additional seven regional hospital-based proton therapy centers in the United States alone, and many more worldwide.[22] As of 2020, five manufacturers make proton therapy systems: Mevion Medical Systems, Ion Beam Applications, Hitachi, ProTom International and Varian Medical Systems.

Application

It was estimated that by the end of 2017, a total of ~175,000 patients had been treated with proton therapy. Physicians use protons to treat conditions in two broad categories:

  • Disease sites that respond well to higher doses of radiation, i.e., dose escalation. In some instances, dose escalation has demonstrated a higher probability of "cure" (i.e., local control) than conventional radiotherapy.[23] These include, among others, uveal melanoma (ocular tumors), skull base and paraspinal tumors (chondrosarcoma and chordoma), and unresectable sarcomas. In all these cases proton therapy achieves significant improvements in the probability of local control over conventional radiotherapy.[24][25][26] In treatment of ocular tumors, proton therapy also has high rates of maintaining the natural eye.[27]
  • Treatments where proton therapy's increased precision reduces unwanted side effects by lessening the dose to normal tissue. In these cases, the tumor dose is the same as in conventional therapy, so there is no expectation of an increased probability of curing the disease. Instead, the emphasis is on reducing the integral dose to normal tissue, thus reducing unwanted effects.[23]

Two prominent examples are pediatric neoplasms (such as medulloblastoma) and prostate cancer.

Pediatric treatments

Irreversible long-term side effects of conventional radiation therapy for pediatric cancers have been well documented and include growth disorders, neurocognitive toxicity, ototoxicity with subsequent effects on learning and language development, and renal, endocrine and gonadal dysfunctions. Radiation-induced secondary malignancy is another very serious adverse effect that has been reported. As there is minimal exit dose when using proton radiation therapy, the dose to surrounding normal tissues can be significantly limited, reducing the acute toxicity which positively impacts the risk for these long-term side effects. Cancers requiring craniospinal irradiation, for example, benefit from the absence of exit dose with proton therapy: dose to the heart, mediastinum, bowel, bladder and other tissues anterior to the vertebrae is eliminated, resulting in a reduction of acute thoracic, gastrointestinal and bladder side effects.[28]

Prostate cancer

In prostate cancer cases, the issue is less clear. Some published studies found a reduction in long term rectal and genito-urinary damage when treating with protons rather than photons (meaning X-ray or gamma ray therapy). Others showed a small difference, limited to cases where the prostate is particularly close to certain anatomical structures.[29][30] The relatively small improvement found may be the result of inconsistent patient set-up and internal organ movement during treatment, which offsets most of the advantage of increased precision.[30][31][31][32] One source suggests that dose errors around 20% can result from motion errors of just 2.5 mm (0.098 in). and another that prostate motion is between 5–10 mm (0.20–0.39 in).[33]

However, the number of cases of prostate cancer diagnosed each year far exceeds those of the other diseases referred to above, and this has led some, but not all, facilities to devote a majority of their treatment slots to prostate treatments. For example, two hospital facilities devote roughly 65%[34] and 50%[35] of their proton treatment capacity to prostate cancer, while a third devotes only 7.1%.[36]

Overall worldwide numbers are hard to compile, but one example states that in 2003 roughly 26% of proton therapy treatments worldwide were for prostate cancer.[37]

Eye tumors

Proton therapy for ocular (eye) tumors is a special case since this treatment requires only comparatively low energy protons (about 70 MeV). Owing to this low energy requirement, some particle therapy centers only treat ocular tumors.[20] Proton, or more generally, hadron therapy of tissue close to the eye affords sophisticated methods to assess the alignment of the eye that can vary significantly from other patient position verification approaches in image guided particle therapy.[38] Position verification and correction must ensure that the radiation spares sensitive tissue like the optic nerve to preserve the patient's vision.

Head and neck tumors

Proton particles do not deposit exit dose, which allows proton therapy to spare normal tissues distal to the tumor target. This is particularly useful for treating head and neck tumors because of the anatomic constraints encountered in nearly all cancers in this region. The dosimetric advantage unique to proton therapy translates into toxicity reduction. For recurrent head and neck cancer requiring reirradiation, proton therapy is able to maximize a focused dose of radiation to the tumor while minimizing dose to surrounding tissues which results in a minimal acute toxicity profile, even in patients who have received multiple prior courses of radiotherapy.[39]

Lymphoma (Tumors of lymphatic tissue)

Although chemotherapy is the primary treatment for patients with lymphoma, consolidative radiation is often used in Hodgkin lymphoma and aggressive non-Hodgkin lymphoma, while definitive treatment with radiation alone is used in a small fraction of lymphoma patients. Unfortunately, treatment-related toxicities caused by chemotherapy agents and radiation exposure to healthy tissues are major concerns for lymphoma survivors. Advanced radiation therapy technologies such as proton therapy may offer significant and clinically relevant advantages such as sparing important organs at risk and decreasing the risk for late normal tissue damage while still achieving the primary goal of disease control. This is especially important for lymphoma patients who are being treated with curative intent and have long life expectancies following therapy.[40]

Gastrointestinal malignancy

An increasing amount of data has shown that proton therapy has great potential to increase therapeutic tolerance for patients with GI malignancies. The possibility of decreasing radiation dose to organs at risk may also help facilitate chemotherapy dose escalation or allow for new chemotherapy combinations. Proton therapy will play a decisive role in the context of ongoing intensified combined modality treatments for GI cancers. The following review presents the benefits of proton therapy in treating hepatocellular carcinoma, pancreatic cancer and esophageal cancer.[41]

Comparison with other treatments

The issue of when, whether, and how best to apply this technology is controversial.[42][43] As of 2012 there have been no controlled trials to demonstrate that proton therapy yields improved survival or other clinical outcomes (including impotence in prostate cancer) compared to other types of radiation therapy, although a five-year study of prostate cancer is underway at Massachusetts General Hospital.[44][45][46][47][47]

The cost of proton therapy depends on your insurance provider, condition, medical history, and number of treatments. Long-term costs could be lower for the patient, depending on side effects.[48][49]

Preliminary results from a 2009 study, including high-dose treatments, showed very few side effects.[50]

NHS Choices has stated:

We cannot say with any conviction that proton beam therapy is “better” overall than radiotherapy. (...) Some overseas clinics providing proton beam therapy heavily market their services to parents who are understandably desperate to get treatment for their children. Proton beam therapy can be very costly and it is not clear whether all children treated privately abroad are treated appropriately.[51][52]

X-ray radiotherapy
Irradiation of nasopharyngeal carcinoma by photon (X-ray) therapy (left) and proton therapy (right)

The figure at the right of the page shows how beams of X-rays (IMRT; left frame) and beams of protons (right frame), of different energies, penetrate human tissue. A tumor with a sizable thickness is covered by the IMRT spread out Bragg peak (SOBP) shown as the red lined distribution in the figure. The SOBP is an overlap of several pristine Bragg peaks (blue lines) at staggered depths.

Megavoltage X-ray therapy has less "skin scarring potential" than proton therapy: X-ray radiation at the skin, and at very small depths, is lower than for proton therapy. One study estimates that passively scattered proton fields have a slightly higher entrance dose at the skin (~75%) compared to therapeutic megavoltage (MeV) photon beams (~60%).[2] X-ray radiation dose falls off gradually, unnecessarily damaging tissue deeper in the body and damaging the skin and surface tissue opposite the beam entrance. The differences between the two methods depends on the:

  • Width of the SOBP
  • Depth of the tumor
  • Number of beams that treat the tumor

The X-ray advantage of reduced damage to skin at the entrance is partially counteracted by damage to skin at the exit point.

Since X-ray treatments are usually done with multiple exposures from opposite sides, each section of skin is exposed to both entering and exiting X-rays. In proton therapy, skin exposure at the entrance point is higher, but tissues on the opposite side of the body to the tumor receive no radiation. Thus, X-ray therapy causes slightly less damage to the skin and surface tissues, and proton therapy causes less damage to deeper tissues in front of and beyond the target.[4]

An important consideration in comparing these treatments is whether the equipment delivers protons via the scattering method (historically, the most common) or a spot scanning method. Spot scanning can adjust the width of the SOBP on a spot-by-spot basis, which reduces the volume of normal (healthy) tissue inside the high dose region. Also, spot scanning allows for intensity modulated proton therapy (IMPT), which determines individual spot intensities using an optimization algorithm that lets the user balance the competing goals of irradiating tumors while sparing normal tissue. Spot scanning availability depends on the machine and the institution. Spot scanning is more commonly known as pencil-beam scanning and is available on IBA, Hitachi, Mevion (known as hyperscan[53] and not US FDA approved as of 2015) and Varian.

Surgery

Physicians base the decision to use surgery or proton therapy (or any radiation therapy) on the tumor type, stage, and location. In some instances, surgery is superior (such as cutaneous melanoma), in some instances radiation is superior (such as skull base chondrosarcoma), and in some instances they are comparable (for example, prostate cancer). In some instances, they are used together (e.g., rectal cancer or early stage breast cancer).

The benefit of external beam proton radiation lies in the dosimetric difference from external beam X-ray radiation and brachytherapy in cases where the use of radiation therapy is already indicated, rather than as a direct competition with surgery.[23] However, in the case of prostate cancer, the most common indication for proton beam therapy, no clinical study directly comparing proton therapy to surgery, brachytherapy, or other treatments has shown any clinical benefit for proton beam therapy. Indeed, the largest study to date showed that IMRT compared with proton therapy was associated with less gastrointestinal morbidity.[54]

Side effects and risks
Main articles: Radiation therapy § Side effects, and Adverse effect

Proton therapy is a type of external beam radiotherapy, and shares risks and side effects of other forms of radiation therapy. However the dose outside of the treatment region can be significantly less for deep-tissue tumors than X-ray therapy, because proton therapy takes full advantage of the Bragg peak. Proton therapy has been in use for over 40 years, and is a mature treatment technology. However, as with all medical knowledge, understanding of the interaction of radiation (proton, X-ray, etc.) with tumor and normal tissue is still imperfect.[42]

Costs

Historically, proton therapy has been expensive. An analysis published in 2003 determined the relative cost of proton therapy is approximately 2.4 times that of X-ray therapies.[55] Newer, less expensive, and dozens more proton treatment centers are driving costs down and they offer more accurate three-dimensional targeting. Higher proton dosage over fewer treatments sessions (1/3 fewer or less) is also driving costs down.[56][57] Thus the cost is expected to reduce as better proton technology becomes more widely available. An analysis published in 2005 determined that the cost of proton therapy is not unrealistic and should not be the reason for denying patients access to the technology.[58] In some clinical situations, proton beam therapy is clearly superior to the alternatives.[59][60]

A study in 2007 expressed concerns about the effectiveness of proton therapy for treating prostate cancer,[61] but with the advent of new developments in the technology, such as improved scanning techniques and more precise dose delivery ('pencil beam scanning'), this situation may change considerably.[62] Amitabh Chandra, a health economist at Harvard University, stated, "Proton-beam therapy is like the Death Star of American medical technology... It's a metaphor for all the problems we have in American medicine.”[63] Proton therapy is cost-effective for some types of cancer, but not all.[64][65] In particular, some other treatments offer better overall value for treatment of prostate cancer.[66]

As of 2018, the cost of a single-room particle therapy system is US$40 million, with multi-room systems costing up to US$200 million.[67][68]

Treatment centers
Control panel of the synchrocyclotron at the Orsay proton therapy center, France

As of July 2017, there are over 75 particle therapy facilities worldwide,[69] with at least 41 others under construction.[70] As of June 2018, there are 27 operational proton therapy centers in the United States. As of the end of 2015 more than 154,203 patients had been treated worldwide.[71]

One hindrance to universal use of the proton in cancer treatment is the size and cost of the cyclotron or synchrotron equipment necessary. Several industrial teams are working on development of comparatively small accelerator systems to deliver the proton therapy to patients.[72] Among the technologies being investigated are superconducting synchrocyclotrons (also known as FM Cyclotrons), ultra-compact synchrotrons, dielectric wall accelerators,[72] and linear particle accelerators.[57]

United States

Proton treatment centers in the United States as of 2017 (in chronological order of first treatment date) include:[21][73]

Institution Location Year of first treatment Comments
Loma Linda University Medical Center[74] Loma Linda, CA 1990 First hospital-based facility in USA; uses Spread Out Bragg's Peak (SOBP)
Crocker Nuclear Laboratory[75] Davis, CA 1994 Ocular treatments only (low energy accelerator); at University of California, Davis
Francis H. Burr Proton Center Boston, MA 2001 At Massachusetts General Hospital and formerly known as NPTC; continuation of Harvard Cyclotron Laboratory/MGH treatment program that began in 1961; Manufactured by Ion Beam Applications[76]
University of Florida Health Proton Therapy Institute-Jacksonville[77] Jacksonville, FL 2006 The UF Health Proton Therapy Institute is a part of a non-profit academic medical research facility affiliated with the University of Florida College of Medicine-Jacksonville. It is the first treatment center in the Southeast U.S. to offer proton therapy. Manufactured by Ion Beam Applications[76]
University of Texas MD Anderson Cancer Center[78] Houston, TX 2006
Oklahoma Proton Center[79] Oklahoma City, OK 2009 4 treatment rooms, Proteus PLUS system manufactured by Ion Beam Applications[76]
Northwestern Medicine Chicago Proton Center Warrenville, IL 2010 4 treatment rooms, Proteus PLUS system manufactured by Ion Beam Applications[76]
Roberts Proton Therapy Center[80] Philadelphia, PA 2010 The largest proton therapy center in the world, the Roberts Proton Therapy Center, which is a part of Penn's Abramson Cancer Center, University of Pennsylvania Health System; 5 treatment rooms, Proteus PLUS system manufactured by Ion Beam Applications[76]
Hampton University Proton Therapy Institute Hampton, VA 2010 5 treatment rooms, Proteus PLUS system manufactured by Ion Beam Applications[76]
ProCure Proton Therapy Center[81] Somerset, NJ 2012 4 treatment rooms, Proteus PLUS system manufactured by Ion Beam Applications[76]
SCCA Proton Therapy Center Seattle, WA 2013 At Seattle Cancer Care Alliance; part of Fred Hutchinson Cancer Research Center; 4 treatment rooms, Proteus PLUS system manufactured by Ion Beam Applications[76]
Siteman Cancer Center[56] St. Louis, MO 2013 First of the new single suite, ultra-compact, superconducting synchrocyclotron,[82] lower cost facilities to treat a patient using the Mevion Medical System's S250.[83]
Provision Proton Therapy Center[84] Knoxville, TN 2014 3 treatment rooms, Proteus PLUS system manufactured by Ion Beam Applications[76]
California Protons Cancer Therapy Center[85] San Diego, CA 2014 (5 treatment rooms, manufactured by Varian Medical Systems[86]
Ackerman Cancer Center Jacksonville, FL 2015 Ackerman Cancer Center is the world's first private, physician-owned practice to provide proton therapy, in addition to conventional radiation therapy and on-site diagnostic services.
The Laurie Proton Therapy Center New Brunswick, NJ 2015 The Laurie Proton Therapy Center, part of Robert Wood Johnson University Hospital, is home to the world's third MEVION S250 Proton Therapy System.
Texas Center for Proton Therapy Dallas Fort Worth, TX 2015 A collaboration by "Texas Oncology and The US Oncology Network, supported by McKesson Specialty Health, and Baylor Health Enterprises"; three pencil beam rooms and cone beam CT imaging.[87] 3 treatment rooms, Proteus PLUS system manufactured by Ion Beam Applications[76]
Mayo Clinic Cancer Center Phoenix, AZ 2016 4 treatment rooms.[88] Manufactured by Hitachi.[89]
Mayo Clinic Jacobson Building Rochester, MN 2015 4 treatment rooms.[90] Manufactured by Hitachi.[91]
St. Jude Red Frog Events Proton Therapy Center Memphis, TN 2015 3 treatment rooms
The Marjorie and Leonard Williams Center for Proton Therapy Orlando, FL 2016 http://www.ufhealthcancerorlando.com/centers/proton-therapy-center
Cancer and Blood Diseases Institute Liberty Township, OH 2016 Collaboration of University of Cincinnati Cancer Institute and Cincinnati Children's Hospital Medical Center,[92][93] manufactured by Varian Medical Systems
Maryland Proton Treatment Center Baltimore, MD 2016 5 treatment rooms, affiliated with the University of Maryland Greenebaum Comprehensive Cancer Center, manufactured by Varian Medical Systems.
Proton Therapy Center at University Hospitals Seidman Cancer Center Cleveland, OH 2016 Only proton therapy center in Northern Ohio. One treatment room with the Mevion S250 Proton Therapy System. Part of the NCI-designated Case Comprehensive Cancer Center, University Hospitals Seidman Cancer Center is one of the nation's leading freestanding cancer hospitals.
Miami Cancer Institute Miami, FL 2017 3 treatment rooms, all using pencil-beam scanning[94] Manufactured by Ion Beam Applications[76]
Beaumont Proton Therapy Center Royal Oak, MI 2017 Single treatment room, Proteus ONE system manufactured by Ion Beam Applications[76]
Emory Proton Therapy Center Atlanta, GA 2018 Five treatment rooms, ProBeam Superconducting Cyclotron[95] manufactured by Varian Medical Systems
Provision CARES Proton Therapy Center Nashville, TN 2018 Three treatment rooms, Two Gantries and One Fixed Beam, All Pencil Beam Scanning, manufactured by ProNova Solutions, LLC
New York Proton Center New York, NY 2019 Four treatment rooms, manufactured by Varian Medical Systems
South Florida Proton Therapy Institute Delray Beach, FL 2019 One treatment room, manufactured by Varian Medical Systems
UAB Proton Therapy Center Birmingham, AL 2020 One treatment room, manufactured by Varian Medical Systems
University of Miami Miami, FL 2020 One treatment room, manufactured by Varian Medical Systems
The University of Kansas Cancer Center Kansas City, KS 2021 (Estimated) Announced Feb 2019[96]
Penn Medicine Lancaster General Health Ann B. Barshinger Cancer Institute Lancaster, PA 2021 (Estimated) One treatment room, manufactured by Varian Medical Systems
Mayo Clinic Florida Jacksonville, FL 2023 (Estimated) Announced June 2019[97]

The Indiana University Health Proton Therapy Center in Bloomington, Indiana opened in 2004 and ceased operations in 2014.

Outside the US
Proton therapy Centres (partial list)[21]
Institution Maximum energy (MeV) Year of first treatment Location
Paul Scherrer Institute 250 1984 Villigen, Switzerland
Clatterbridge Cancer Centre NHS Foundation Trust, low-energy for ocular[98] 62 1989 Liverpool, United Kingdom
Centre de protonthérapie de l'Institut Curie 235 1991 Orsay, France
Centre Antoine Lacassagne 63 1991 Nice, France
Research Center for Charged Particle Therapy 350–400 1994 Chiba, Japan
TRIUMF[99] 74 1995 Vancouver, Canada
Helmholtz-Zentrum Berlin 72 1998 Berlin, Germany
Proton Medical Research Center University of Tsukuba 250 2001 Tsukuba, Japan
Centro di adroterapia oculare 60 2002 Catania, Italy
Wanjie Proton Therapy Center 230 2004 Zibo, China
Proton Therapy Center, Korea National Cancer Center 230 2007 Seoul, Korea
Heidelberg Ion-Beam Therapy Center 230 2009 Heidelberg, Germany
Rinecker Proton Therapy Center 250 2009 Munich, Germany
Medipolis Proton Therapy and Research Center 235 2011 Kagoshima, Japan
Instytut Fizyki Jądrowej 230 2011 Kraków, Poland
Centro Nazionale di Adroterapia Oncologica 250 2011 Pavia, Italy
Proton Therapy Center, Prague 230 2012 Prague, Czech Republic
Westdeutsches Protonentherapiezentrum 230 2013 Essen, Germany
PTC Uniklinikum 230 2014 Dresden, Germany
Centro di Protonterapia, APSS Trento[100] 230 2014 Trento, Italy
Shanghai Proton and Heavy Ion Center 230 2014 Shanghai, China
Centrum Cyklotronowe Bronowice 230 2015 Kraków, Poland
SMC Proton Therapy Center 230 2015 Seoul, Korea
Proton and Radiation Therapy Center, Linkou Chang Gung Memorial Hospital 230 2015 Taipei, Taiwan
Yung-Ching Proton Center, Kaohsiung Chang Gung Memorial Hospital[101] 230 2018 Kaohsiung, Taiwan
Skandionkliniken[102] 230 2015 Uppsala, Sweden
A. Tsyb Medical Radiological Research Centre 250 2016 Obninsk, Russia
Clinical Proton Therapy Center Dr. Berezin Medical Institute[103] 250 2017 Saint-Petersburg, Russia
Holland Proton Therapy Center[104] 250 2018 Delft, Netherlands
UMC Groningen Protonen Therapie Centrum[105] 230 2018 Groningen, Netherlands
The Christie[106] 250 2018 Manchester, UK
Danish Centre for Particle Therapy[107] 250 2019 Aarhus, Denmark
Proton Therapy Centre Apollo Hostpitals[108] 230 2019 Chennai, India
University College London Hospitaals[109] 250 2020 London, UK
Singapore Institute of Advanced Medicine[110] 250 2020 Singapore
Australian Bragg Centre for Proton Therapy & Research[111][112] 330 2023–2025 Adelaide, Australia

United Kingdom

In 2013 the British government announced that £250 million had been budgeted to establish two centers for advanced radiotherapy, to open in 2018 at The Christie NHS Foundation Trust in Manchester and University College London Hospitals NHS Foundation Trust. These would offer high-energy proton therapy, currently unavailable in the UK, as well as other types of advanced radiotherapy, including intensity-modulated radiotherapy (IMRT) and image-guided radiotherapy (IGRT).[113] In 2014, only low-energy proton therapy was available in the UK, at the Clatterbridge Cancer Centre NHS Foundation Trust in Merseyside. But NHS England has paid to have suitable cases treated abroad, mostly in the US. Such cases have risen from 18 in 2008 to 122 in 2013, 99 of whom were children. The cost to the National Health Service averaged around £100,000 per case.[114]

A company named Advanced Oncotherapy plc and its subsidiary ADAM, a spin-off from CERN, are developing a linear proton therapy accelerator to be installed among others in London. In 2015 they signed a deal with Howard de Walden Estate to install a machine in Harley Street, the heart of private medicine in London.[115] First patient treatment at Harley Street is expected in the second half of 2020.[116]

Proton Partners International has constructed the UK's only network of centres, based in Newport, Northumberland, Reading and Liverpool. The Newport Centre in South Wales was the first to treat a patient in the UK with high-energy proton therapy in 2018. the Northumberland centre opened in early 2019. The Reading centre opened in mid-2019. The Liverpool centre is due to open in mid-2020.

Australia

In July 2020, construction began for "SAHMRI 2", the second building for the South Australian Health and Medical Research Institute. The building will house the Australian Bragg Centre for Proton Therapy & Research, a A$500+ million addition to the largest health and biomedical precinct in the Southern Hemisphere, Adelaide’s BioMed City. The proton therapy unit is being supplied by ProTom International, which will install its Radiance 330 proton therapy system, the same system used at Massachusetts General Hospital. When in full operation, it will have the ability to treat approximately 600-700 patients per year with around half of these expected to be children and young adults. The facility is expected to be completed in late 2023, with its first patients treated in 2025.[112]

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See also

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Further reading
  • Greco C.; Wolden S. (Apr 2007). "Current status of radiotherapy with proton and light ion beams". Cancer. 109 (7): 1227–1238. doi:10.1002/cncr.22542. PMID 17326046.
  • "Use of Protons for Radiotherapy", A.M. Koehler, Proc. of the Symposium on Pion and Proton Radiotherapy, Nat. Accelerator Lab., (1971).
  • A.M. Koehler, W.M. Preston, "Protons in Radiation Therapy: comparative Dose Distributions for Protons, Photons and Electrons Radiology 104(1):191–195 (1972).
  • "Bragg Peak Proton Radiosurgery for Arteriovenous Malformation of the Brain" R.N. Kjelberg, presented at First Int. Seminar on the Use of Proton Beams in Radiation Therapy, Moskow (1977).
  • Austin-Seymor, M.J. Munzenrider, et al. "Fractionated Proton Radiation Therapy of Cranial and Intracrainial Tumors" Am. J. of Clinical Oncology 13(4):327–330 (1990).
  • "Proton Radiotherapy", Hartford, Zietman, et al. in Radiotheraputic Management of Carcinoma of the Prostate, A. D'Amico and G.E. Hanks. London, UK, Arnold Publishers: 61–72 (1999).
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