Plasminogen activator Pla

Plasminogen activator Pla (EC 3.4.23.48) is an enzyme.[1] This enzyme catalyses the following chemical reaction

Converts human Glu-plasminogen to plasmin by cleaving the Arg560-Val peptide bond that is also hydrolysed by the mammalian u-plasminogen activator and t-plasminogen activator. Also cleaves arginyl bonds in other proteins
Plasminogen activator Pla
Identifiers
EC number3.4.23.48
CAS number101028-08-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is isolated from the bacterium Yersinia pestis that causes plague.

References

  1. Kukkonen M, Lähteenmäki K, Suomalainen M, Kalkkinen N, Emödy L, Lång H, Korhonen TK (June 2001). "Protein regions important for plasminogen activation and inactivation of alpha2-antiplasmin in the surface protease Pla of Yersinia pestis". Molecular Microbiology. 40 (5): 1097–111. doi:10.1046/j.1365-2958.2001.02451.x. PMID 11401715.
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