Phosphonoacetate hydrolase
In enzymology, a phosphonoacetate hydrolase (EC 3.11.1.2) is an enzyme that catalyzes the chemical reaction
- phosphonoacetate + H2O acetate + phosphate
| phosphonoacetate hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure of phosphonoacetate hydrolase. PDB entry 1e16. Zinc ions and phosphonoformate are shown in the active site. | |||||||||
| Identifiers | |||||||||
| EC number | 3.11.1.2 | ||||||||
| CAS number | 153570-68-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are phosphonoacetate and H2O, whereas its two products are acetate and phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on carbon-phosphorus bonds. The systematic name of this enzyme class is phosphonoacetate phosphonohydrolase. This enzyme participates in aminophosphonate metabolism. It employs one cofactor, zinc.
Structural studies
The structure of this enzyme, with the PDB accession code 1EI6, shows it adopts the alkaline phosphatase fold.
gollark: Although many tasks don't need generalized robots as much as big motors or something.
gollark: On the other hand, modern robot-y systems need microprocessors, which are stupidly expensive and hard to make, and humans wouldn't.
gollark: Currently they mostly can't, although the tech *is* improving and the logistics of supplying electricity and spare parts might be better than having to deal with food and everything else.
gollark: They could still revolt or something.
gollark: Managing all the slaves would be time-consuming. You could delegate it, but then you have to worry about supplying them.
References
- McGrath JW, Wisdom GB, McMullan G, Larkin MJ, Quinn JP (1995). "The purification and properties of phosphonoacetate hydrolase, a novel carbon-phosphorus bond-cleavage enzyme from Pseudomonas fluorescens 23F". Eur. J. Biochem. 234 (1): 225–30. doi:10.1111/j.1432-1033.1995.225_c.x. PMID 8529644.
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