Phosphoamidase

In enzymology, a phosphoamidase (EC 3.9.1.1) is an enzyme that catalyzes the chemical reaction

N-phosphocreatine + H2O creatine + phosphate
phosphoamidase
Identifiers
EC number3.9.1.1
CAS number9001-79-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are N-phosphocreatine and H2O, whereas its two products are creatine and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphorus-nitrogen bonds. The systematic name of this enzyme class is phosphamide hydrolase. This enzyme is also called creatine phosphatase.

References

    • Parvin R, Smith RA (1969). "Phosphoramidates. V. Probable identity of rat liver microsomal glucose 6-phosphatase, phosphoramidase, and phosphoramidate-hexose phosphotransferase". Biochemistry. 8 (4): 1748–55. doi:10.1021/bi00832a058. PMID 4308726.
    • Singer MF; Fruton JS (1957). "Some properties of beef spleen phosphoamidase". J. Biol. Chem. 229 (1): 111–119. PMID 13491564.
    • Sundarajan TA; Sarma PS (1959). "Substrate specificity of phosphoprotein phosphatase from spleen". Biochem. J. 71: 537–544.


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