PFKFB1

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene.[5][6]

PFKFB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1K6M
Identifiers
Aliases	PFKFB1, F6PK, HL2K, PFRX, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
External IDs	OMIM: 311790 MGI: 107816 HomoloGene: 105654 GeneCards: PFKFB1
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.21 Start 54,932,961 bp[1] End 54,998,534 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F3 Start 150,588,229 bp[2] End 150,643,878 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • fructose-6-phosphate binding • kinase activity • catalytic activity • GO:0001948 protein binding • identical protein binding • fructose-2,6-bisphosphate 2-phosphatase activity • hydrolase activity • ATP binding • 6-phosphofructo-2-kinase activity • kinase binding Cellular component • cytosol • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex Biological process • gluconeogenesis • response to glucagon • glycolytic process • phosphorylation • fructose metabolic process • response to glucocorticoid • carbohydrate phosphorylation • response to insulin • positive regulation of glucokinase activity • fructose 2,6-bisphosphate metabolic process • animal organ regeneration • response to starvation • metabolism • response to cAMP • dephosphorylation • negative regulation of glycolytic process • positive regulation of glycolytic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5207	18639
Ensembl	ENSG00000158571	ENSMUSG00000025271
UniProt	P16118	P70266
RefSeq (mRNA)	NM_001271804 NM_001271805 NM_002625	NM_008824 NM_001374170 NM_001374171 NM_001374172 NM_001374173 NM_001374175
RefSeq (protein)	NP_001258733 NP_001258734 NP_002616	NP_032850 NP_001361099 NP_001361100 NP_001361101 NP_001361102 NP_001361104
Location (UCSC)	Chr X: 54.93 – 55 Mb	Chr X: 150.59 – 150.64 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000158571 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025271 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Batra RS, Hatchwell E, Rider S, Brown R, Brown GK, Craig IW (Apr 1997). "Localization of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB1) within a YAC contig in Xp11.21". Genomics. 40 (2): 358–61. doi:10.1006/geno.1996.4530. PMID 9119406.
6. "Entrez Gene: PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1".

Further reading

• Lange AJ, Pilkis SJ (1990). "Sequence of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase". Nucleic Acids Res. 18 (12): 3652. doi:10.1093/nar/18.12.3652. PMC 331036. PMID 2163524.
• Marker AJ, Colosia AD, Tauler A, et al. (1989). "Glucocorticoid regulation of hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression". J. Biol. Chem. 264 (12): 7000–4. PMID 2540168.
• Algaier J, Uyeda K (1988). "Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6-P,2-kinase:fructose-2,6-bisphosphatase". Biochem. Biophys. Res. Commun. 153 (1): 328–33. doi:10.1016/S0006-291X(88)81226-9. PMID 2837207.
• Lee YH, Li Y, Uyeda K, Hasemann CA (2003). "Tissue-specific structure/function differentiation of the liver isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase". J. Biol. Chem. 278 (1): 523–30. doi:10.1074/jbc.M209105200. PMID 12379646.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.