PANK1

Pantothenate kinase 1 is an enzyme that in humans is encoded by the PANK1 gene.[5]

PANK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2I7N, 3SMP
Identifiers
Aliases	PANK1, PANK, pantothenate kinase 1
External IDs	OMIM: 606160 MGI: 1922985 HomoloGene: 56979 GeneCards: PANK1
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q23.31 Start 89,579,497 bp[1] End 89,645,572 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 C1|19 Start 34,806,940 bp[2] End 34,879,455 bp[2]
Gene ontology Molecular function • kinase activity • ATP binding • nucleotide binding • transferase activity • pantothenate kinase activity • protein homodimerization activity • acetyl-CoA binding Cellular component • cell nucleus • clathrin coat • cell periphery • cytosol • recycling endosome • cytoplasm Biological process • coenzyme A biosynthetic process • phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	53354	75735
Ensembl	ENSG00000152782	ENSMUSG00000033610
UniProt	Q8TE04	Q8K4K6
RefSeq (mRNA)	NM_138316 NM_148977 NM_148978	NM_001114339 NM_023792
RefSeq (protein)	NP_612189 NP_683878 NP_683879	NP_001107811 NP_076281
Location (UCSC)	Chr 10: 89.58 – 89.65 Mb	Chr 19: 34.81 – 34.88 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein belonging to the pantothenate kinase family, which in mammals is made of up PANK1, PANK2, PANK3, and PANK4. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, have been identified.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000152782 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033610 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PANK1 pantothenate kinase 1".

Further reading

• Robishaw JD, Neely JR (1985). "Coenzyme A metabolism". Am. J. Physiol. 248 (1 Pt 1): E1–9. PMID 2981478.
• Hong BS, Senisterra G, Rabeh WM, et al. (2007). "Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder". J. Biol. Chem. 282 (38): 27984–93. doi:10.1074/jbc.M701915200. PMID 17631502.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Ramaswamy G, Karim MA, Murti KG, Jackowski S (2004). "PPARalpha controls the intracellular coenzyme A concentration via regulation of PANK1alpha gene expression". J. Lipid Res. 45 (1): 17–31. doi:10.1194/jlr.M300279-JLR200. PMID 14523052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Westaway SK, Hayflick SJ, Zhou B, Gitschier JD (2003). "In reference to the Short Communication published by Ni et al". Int. J. Biochem. Cell Biol. 34 (12): 1629. doi:10.1016/S1357-2725(02)00125-5. PMID 12379284.
• Zhou B, Westaway SK, Levinson B, et al. (2001). "A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome". Nat. Genet. 28 (4): 345–9. doi:10.1038/ng572. PMID 11479594.