PANK4

Pantothenate kinase 4 is an enzyme (pantothenate kinase) that in humans is encoded by the PANK4 gene.[5][6]

PANK4
Identifiers
Aliases	PANK4, pantothenate kinase 4, pantothenate kinase 4 (inactive)
External IDs	OMIM: 606162 MGI: 2387466 HomoloGene: 41235 GeneCards: PANK4
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.32 Start 2,508,537 bp[1] End 2,526,611 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 E2 Start 154,964,123 bp[2] End 154,980,938 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • pantothenate kinase activity • ATP binding • kinase activity Cellular component • cytoplasm Biological process • coenzyme A biosynthetic process • phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55229	269614
Ensembl	ENSG00000157881 ENSG00000273494	ENSMUSG00000029056
UniProt	Q9NVE7	Q80YV4
RefSeq (mRNA)	NM_018216	NM_172990 NM_001305804
RefSeq (protein)	NP_060686	NP_001292733 NP_766578
Location (UCSC)	Chr 1: 2.51 – 2.53 Mb	Chr 4: 154.96 – 154.98 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues.[6]

See also

• Coenzyme A
• Pantothenate

References

1. ENSG00000273494 GRCh38: Ensembl release 89: ENSG00000157881, ENSG00000273494 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029056 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhou B, Westaway SK, Levinson B, Johnson MA, Gitschier J, Hayflick SJ (Jul 2001). "A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome". Nat Genet. 28 (4): 345–9. doi:10.1038/ng572. PMID 11479594.
6. "Entrez Gene: PANK4 pantothenate kinase 4".

Further reading

• Robishaw JD, Neely JR (1985). "Coenzyme A metabolism". Am. J. Physiol. 248 (1 Pt 1): E1–9. PMID 2981478.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Li Y, Chang Y, Zhang L, et al. (2005). "High glucose upregulates pantothenate kinase 4 (PanK4) and thus affects M2-type pyruvate kinase (Pkm2)". Mol. Cell. Biochem. 277 (1–2): 117–25. doi:10.1007/s11010-005-5535-1. PMID 16132722.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.