Nupapillomavirus

Nupapillomavirus is a genus of viruses, in the family Papillomaviridae[1]. Humans serve as natural hosts. There is currently only one species in this genus: the type species Nupapillomavirus 1. Diseases associated with this genus include: facial warts. It has also been detected in some skin carcinomas and premalignant keratoses.[2][3]

Nupapillomavirus
Virus classification
(unranked): Virus
Realm: Monodnaviria
Kingdom: Shotokuvirae
Phylum: Cossaviricota
Class: Papovaviricetes
Order: Zurhausenvirales
Family: Papillomaviridae
Genus: Nupapillomavirus
Type species
Nupapillomavirus 1

Taxonomy

Group: dsDNA

[3]

Structure

Viruses in Nupapillomavirus are non-enveloped, with icosahedral geometries, and T=7 symmetry. The diameter is around 52-55 nm. Genomes are circular, around 8kb in length.[2]

GenusStructureSymmetryCapsidGenomic arrangementGenomic segmentation
NupapillomavirusIcosahedralT=7Non-envelopedCircularMonopartite

Life cycle

Viral replication is nuclear. Entry into the host cell is achieved by attachment of the viral proteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. DNA-templated transcription, with some alternative splicing mechanism is the method of transcription. The virus exits the host cell by nuclear envelope breakdown. Human serve as the natural host. Transmission routes are contact.[2]

GenusHost detailsTissue tropismEntry detailsRelease detailsReplication siteAssembly siteTransmission
NupapillomavirusHumansEpithelial: mucous; epithelial: skinCell receptor endocytosisLysisNucleusNucleusContact
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References
  1. Van Doorslaer, K; Chen, Z; Bernard, HU; Chan, PKS; DeSalle, R; Dillner, J; Forslund, O; Haga, T; McBride, AA; Villa, LL; Burk, RD; ICTV Report Consortium (August 2018). "ICTV Virus Taxonomy Profile: Papillomaviridae". The Journal of General Virology. 99 (8): 989–990. doi:10.1099/jgv.0.001105. PMC 6171710. PMID 29927370.
  2. "Viral Zone". ExPASy. Retrieved 15 June 2015.
  3. "ICTV Report Papillomaviridae".
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