Nuclear mitotic apparatus protein 1

Nuclear mitotic apparatus protein 1 is a protein that in humans is encoded by the NUMA1 gene.[5][6]

NUMA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3RO2
Identifiers
Aliases	NUMA1, NUMA, NMP-22, nuclear mitotic apparatus protein 1
External IDs	OMIM: 164009 MGI: 2443665 HomoloGene: 38150 GeneCards: NUMA1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.4 Start 72,002,864 bp[1] End 72,080,693 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E2 Start 101,934,111 bp[2] End 102,014,964 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • structural molecule activity • GO:0001948 protein binding • microtubule binding • protein C-terminus binding • tubulin binding • phosphatidylinositol binding • microtubule plus-end binding • microtubule minus-end binding • dynein complex binding • disordered domain specific binding • lipid binding • protein domain specific binding • GO:0032403 macromolecular complex binding Cellular component • extracellular exosome • spindle • mitotic spindle • chromosome • microtubule organizing center • Golgi membrane • apical part of cell • mitotic spindle astral microtubule • centrosome • microtubule • neuronal cell body • dendrite • cytoskeleton • spindle microtubule • spindle pole • cell nucleus • cytoplasm • cytosol • nuclear matrix • extrinsic component of plasma membrane • spindle pole centrosome • microtubule plus-end • microtubule minus-end • cortical microtubule • microtubule bundle • mitotic spindle pole • cell cortex region • cytoplasmic microtubule bundle • mitotic spindle midzone • nucleoplasm • cell membrane • cell cortex • membrane • lateral cell cortex • lateral plasma membrane • macromolecular complex Biological process • lung epithelial cell differentiation • cell cycle • cell division • GO:0007126 meiotic cell cycle • nucleus organization • establishment of mitotic spindle orientation • microtubule bundle formation • positive regulation of BMP signaling pathway • astral microtubule organization • positive regulation of microtubule polymerization • positive regulation of intracellular transport • positive regulation of keratinocyte differentiation • positive regulation of hair follicle development • positive regulation of chromosome segregation • anastral spindle assembly • regulation of mitotic spindle organization • regulation of metaphase plate congression • positive regulation of protein localization to spindle pole body • positive regulation of mitotic spindle elongation • positive regulation of protein localization to cell cortex • positive regulation of chromosome separation • positive regulation of spindle assembly • chromosome segregation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4926	101706
Ensembl	ENSG00000137497	ENSMUSG00000066306
UniProt	Q14980 Q3SYK8	E9Q7G0
RefSeq (mRNA)	NM_001286561 NM_006185	NM_133947
RefSeq (protein)	NP_001273490 NP_006176 NP_006176.2	NP_598708
Location (UCSC)	Chr 11: 72 – 72.08 Mb	Chr 7: 101.93 – 102.01 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Nuclear mitotic apparatus protein 1 has been shown to interact with PIM1,[7] Band 4.1,[8] GPSM2[9] and EPB41L1.[10]

References

1. GRCh38: Ensembl release 89: ENSG00000137497 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000066306 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sparks CA, Bangs PL, McNeil GP, Lawrence JB, Fey EG (Oct 1993). "Assignment of the nuclear mitotic apparatus protein NuMA gene to human chromosome 11q13". Genomics. 17 (1): 222–224. doi:10.1006/geno.1993.1307. PMID 8406455.
6. "Entrez Gene: NUMA1 nuclear mitotic apparatus protein 1".
7. Bhattacharya, Nandini; Wang Zeping; Davitt Christine; McKenzie Ian F C; Xing Pei-Xiang; Magnuson Nancy S (Jul 2002). "Pim-1 associates with protein complexes necessary for mitosis". Chromosoma. Germany. 111 (2): 80–95. doi:10.1007/s00412-002-0192-6. ISSN 0009-5915. PMID 12111331.
8. Mattagajasingh, S N; Huang S C; Hartenstein J S; Snyder M; Marchesi V T; Benz E J (Apr 1999). "A nonerythroid isoform of protein 4.1R interacts with the nuclear mitotic apparatus (NuMA) protein". J. Cell Biol. UNITED STATES. 145 (1): 29–43. doi:10.1083/jcb.145.1.29. ISSN 0021-9525. PMC 2148212. PMID 10189366.
9. Du, Q; Stukenberg P T; Macara I G (Dec 2001). "A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization". Nat. Cell Biol. England. 3 (12): 1069–1075. doi:10.1038/ncb1201-1069. ISSN 1465-7392. PMID 11781568.
10. Ye, K; Compton D A; Lai M M; Walensky L D; Snyder S H (Dec 1999). "Protein 4.1N binding to nuclear mitotic apparatus protein in PC12 cells mediates the antiproliferative actions of nerve growth factor". J. Neurosci. UNITED STATES. 19 (24): 10747–56. doi:10.1523/JNEUROSCI.19-24-10747.1999. PMC 6784956. PMID 10594058.

Further reading

• Sun QY, Schatten H (2006). "Role of NuMA in vertebrate cells: review of an intriguing multifunctional protein". Front. Biosci. 11: 1137–46. doi:10.2741/1868. PMID 16146802.
• Yang CH, Lambie EJ, Snyder M (1992). "NuMA: an unusually long coiled-coil related protein in the mammalian nucleus". J. Cell Biol. 116 (6): 1303–1317. doi:10.1083/jcb.116.6.1303. PMC 2289379. PMID 1541630.
• Compton DA, Szilak I, Cleveland DW (1992). "Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis". J. Cell Biol. 116 (6): 1395–1408. doi:10.1083/jcb.116.6.1395. PMC 2289377. PMID 1541636.
• Lydersen BK, Pettijohn DE (1981). "Human-specific nuclear protein that associates with the polar region of the mitotic apparatus: distribution in a human/hamster hybrid cell". Cell. 22 (2 Pt 2): 489–499. doi:10.1016/0092-8674(80)90359-1. PMID 7004645.
• Maekawa T, Kuriyama R (1993). "Primary structure and microtubule-interacting domain of the SP-H antigen: a mitotic MAP located at the spindle pole and characterized as a homologous protein to NuMA". J. Cell Sci. 105 (2): 589–600. PMID 8408288.
• Tang TK, Tang CJ, Chen YL, Wu CW (1993). "Nuclear proteins of the bovine esophageal epithelium. II. The NuMA gene gives rise to multiple mRNAs and gene products reactive with monoclonal antibody W1". J. Cell Sci. 104 (2): 249–60. PMID 8505359.
• Wells RA, Catzavelos C, Kamel-Reid S (1997). "Fusion of retinoic acid receptor alpha to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia". Nat. Genet. 17 (1): 109–113. doi:10.1038/ng0997-109. PMID 9288109.
• Andrade F, Roy S, Nicholson D, et al. (1998). "Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis". Immunity. 8 (4): 451–460. doi:10.1016/S1074-7613(00)80550-6. PMID 9586635.
• Novick D, Kim SH, Fantuzzi G, et al. (1999). "Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response". Immunity. 10 (1): 127–136. doi:10.1016/S1074-7613(00)80013-8. PMID 10023777.
• Mattagajasingh SN, Huang SC, Hartenstein JS, et al. (1999). "A nonerythroid isoform of protein 4.1R interacts with the nuclear mitotic apparatus (NuMA) protein". J. Cell Biol. 145 (1): 29–43. doi:10.1083/jcb.145.1.29. PMC 2148212. PMID 10189366.
• Clark IB, Meyer DI (2000). "Overexpression of normal and mutant Arp1alpha (centractin) differentially affects microtubule organization during mitosis and interphase". J. Cell Sci. 112 (20): 3507–18. PMID 10504299.
• Ye K, Compton DA, Lai MM, et al. (2000). "Protein 4.1N binding to nuclear mitotic apparatus protein in PC12 cells mediates the antiproliferative actions of nerve growth factor". J. Neurosci. 19 (24): 10747–56. doi:10.1523/JNEUROSCI.19-24-10747.1999. PMC 6784956. PMID 10594058.
• Taimen P, Viljamaa M, Kallajoki M (2000). "Preferential expression of NuMA in the nuclei of proliferating cells". Exp. Cell Res. 256 (1): 140–149. doi:10.1006/excr.2000.4799. PMID 10739661.
• Harborth J, Weber K, Osborn M (2000). "GAS41, a highly conserved protein in eukaryotic nuclei, binds to NuMA". J. Biol. Chem. 275 (41): 31979–31985. doi:10.1074/jbc.M000994200. PMID 10913114.
• Gregson HC, Schmiesing JA, Kim JS, et al. (2002). "A potential role for human cohesin in mitotic spindle aster assembly". J. Biol. Chem. 276 (50): 47575–47582. doi:10.1074/jbc.M103364200. PMID 11590136.
• Du Q, Stukenberg PT, Macara IG (2002). "A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization". Nat. Cell Biol. 3 (12): 1069–1075. doi:10.1038/ncb1201-1069. PMID 11781568.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
• Haren L, Merdes A (2002). "Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules". J. Cell Sci. 115 (Pt 9): 1815–24. PMID 11956313.
• Sbodio JI, Chi NW (2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner". J. Biol. Chem. 277 (35): 31887–31892. doi:10.1074/jbc.M203916200. PMID 12080061.

External links

• Overview of all the structural information available in the PDB for UniProt: Q14980 (Nuclear mitotic apparatus protein 1) at the PDBe-KB.