GPSM2

G-protein-signaling modulator 2, also called LGN for its 10 Leucine-Glycine-Asparagine repeats, is a protein that in humans is encoded by the GPSM2 gene.[5][6][7]

GPSM2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3SF4, 4WNE, 4WNF, 4WNG, 5A6C
Identifiers
Aliases	GPSM2, CMCS, DFNB82, LGN, PINS, G-protein signaling modulator 2, G protein signaling modulator 2
External IDs	OMIM: 609245 MGI: 1923373 HomoloGene: 56584 GeneCards: GPSM2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 108,875,350 bp[1] End 108,934,545 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F3 Start 108,678,638 bp[2] End 108,722,309 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein alpha-subunit binding • nucleotide binding • GO:0001948 protein binding • GO:0005083 GTPase regulator activity • identical protein binding • GDP-dissociation inhibitor activity • dynein complex binding • protein C-terminus binding • protein domain specific binding • protein self-association Cellular component • mitotic spindle pole • spindle pole • cytoskeleton • cytosol • cytoplasm • cell cortex region • cell cortex • lateral cell cortex • cell membrane • membrane • lateral plasma membrane • centrosome • macromolecular complex Biological process • GO:0043148 mitotic spindle organization • G-protein coupled receptor signaling pathway • maintenance of centrosome location • GO:0048552 regulation of catalytic activity • Ran protein signal transduction • regulation of mitotic spindle organization • positive regulation of protein localization to cell cortex • positive regulation of spindle assembly • cell cycle • cell division • establishment of mitotic spindle orientation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29899	76123
Ensembl	ENSG00000121957	ENSMUSG00000027883
UniProt	P81274	Q8VDU0
RefSeq (mRNA)	NM_013296 NM_001321038 NM_001321039	NM_029522
RefSeq (protein)	NP_001307967 NP_001307968 NP_037428 NP_037428.3 NP_001307967.1 NP_001307968.1	NP_083798
Location (UCSC)	Chr 1: 108.88 – 108.93 Mb	Chr 3: 108.68 – 108.72 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Heterotrimeric G proteins transduce extracellular signals received by cell surface receptors into integrated cellular responses. GPSM2 belongs to a group of proteins that modulate activation of G proteins (Blumer et al., 2002).[supplied by OMIM][7]

Interactions

GPSM2 has been shown to interact with nuclear mitotic apparatus protein 1[8] and GNAI2.[6][9]

References

1. GRCh38: Ensembl release 89: ENSG00000121957 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027883 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Blumer JB, Chandler LJ, Lanier SM (Apr 2002). "Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis". J. Biol. Chem. 277 (18): 15897–903. doi:10.1074/jbc.M112185200. PMID 11832491.
6. Mochizuki N, Cho G, Wen B, Insel PA (1996). "Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2". Gene. 181 (1–2): 39–43. doi:10.1016/S0378-1119(96)00456-8. PMID 8973305.
7. "Entrez Gene: GPSM2 G-protein signalling modulator 2 (AGS3-like, C. elegans)".
8. Du Q, Stukenberg PT, Macara IG (Dec 2001). "A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization". Nat. Cell Biol. 3 (12): 1069–75. doi:10.1038/ncb1201-1069. PMID 11781568.
9. Marty C, Browning DD, Ye RD (Jun 2003). "Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras". Mol. Cell. Biol. 23 (11): 3847–58. doi:10.1128/MCB.23.11.3847-3858.2003. PMC 155206. PMID 12748287.

Further reading

• Du Q, Stukenberg PT, Macara IG (2001). "A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization". Nat. Cell Biol. 3 (12): 1069–75. doi:10.1038/ncb1201-1069. PMID 11781568.
• Marty C, Browning DD, Ye RD (2003). "Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras". Mol. Cell. Biol. 23 (11): 3847–58. doi:10.1128/MCB.23.11.3847-3858.2003. PMC 155206. PMID 12748287.
• Kaushik R, Yu F, Chia W, Yang X, Bahri S (2003). "Subcellular localization of LGN during mitosis: evidence for its cortical localization in mitotic cell culture systems and its requirement for normal cell cycle progression". Mol. Biol. Cell. 14 (8): 3144–55. doi:10.1091/mbc.E03-04-0212. PMC 181556. PMID 12925752.
• Du Q, Macara IG (2004). "Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins". Cell. 119 (4): 503–16. doi:10.1016/j.cell.2004.10.028. PMID 15537540.
• Yasumi M, Sakisaka T, Hoshino T, Kimura T, Sakamoto Y, Yamanaka T, Ohno S, Takai Y (2005). "Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division". J. Biol. Chem. 280 (8): 6761–5. doi:10.1074/jbc.C400440200. PMID 15632202.
• Yang J, Kamide K, Kokubo Y, Takiuchi S, Tanaka C, Banno M, Miwa Y, Yoshii M, Horio T, Okayama A, Tomoike H, Kawano Y, Miyata T (2005). "Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population". J. Hypertens. 23 (8): 1497–505. doi:10.1097/01.hjh.0000174606.41651.ae. PMID 16003176.
• Izaki T, Kamakura S, Kohjima M, Sumimoto H (2006). "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3". Biochem. Biophys. Res. Commun. 341 (4): 1001–6. doi:10.1016/j.bbrc.2006.01.050. PMID 16458856.

External links

• Overview of all the structural information available in the PDB for UniProt: P81274 (Human G-protein-signaling modulator 2) at the PDBe-KB.
• Overview of all the structural information available in the PDB for UniProt: Q8VDU0 (Mouse G-protein-signaling modulator 2) at the PDBe-KB.