EPB41L1

Band 4.1-like protein 1 is a protein that in humans is encoded by the EPB41L1 gene.[5][6][7]

EPB41L1
Identifiers
AliasesEPB41L1, 4.1N, MRD11, erythrocyte membrane protein band 4.1 like 1
External IDsOMIM: 602879 MGI: 103010 HomoloGene: 8126 GeneCards: EPB41L1
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20q11.23Start36,091,504 bp[1]
End36,232,799 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2036

13821

Ensembl

ENSG00000088367

ENSMUSG00000027624

UniProt

Q9H4G0
Q4VXN0

Q9Z2H5

RefSeq (mRNA)

NM_001258329
NM_001258330
NM_001258331
NM_012156
NM_177996

RefSeq (protein)

NP_001245258
NP_001245259
NP_001245260
NP_036288
NP_818932

Location (UCSC)Chr 20: 36.09 – 36.23 MbChr 2: 156.42 – 156.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Erythrocyte membrane protein band 4.1 (EPB41) is a multifunctional protein that mediates interactions between the erythrocyte cytoskeleton and the overlying plasma membrane. The protein encoded by this gene is a neuronally-enriched protein that is structurally similar to EPB41. The encoded protein binds and stabilizes D2 and D3 dopamine receptors at the neuronal plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them has been determined.[7]

Interactions

EPB41L1 has been shown to interact with:

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References

  1. GRCh38: Ensembl release 89: ENSG00000088367 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027624 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kim AC, Van Huffel C, Lutchman M, Chishti AH (June 1998). "Radiation hybrid mapping of EPB41L1, a novel protein 4.1 homologue, to human chromosome 20q11.2-q12". Genomics. 49 (1): 165–6. doi:10.1006/geno.1998.5212. PMID 9570967.
  6. Peters LL, Weier HU, Walensky LD, Snyder SH, Parra M, Mohandas N, Conboy JG (January 1999). "Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human". Genomics. 54 (2): 348–50. doi:10.1006/geno.1998.5537. PMID 9828140.
  7. "Entrez Gene: EPB41L1 erythrocyte membrane protein band 4.1-like 1".
  8. Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH (December 2000). "Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N". Cell. 103 (6): 919–30. doi:10.1016/S0092-8674(00)00195-1. PMID 11136977.
  9. Binda AV, Kabbani N, Lin R, Levenson R (September 2002). "D2 and D3 dopamine receptor cell surface localization mediated by interaction with protein 4.1N". Mol. Pharmacol. 62 (3): 507–13. doi:10.1124/mol.62.3.507. PMID 12181426.
  10. Maximov A, Tang TS, Bezprozvanny I (February 2003). "Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons". Mol. Cell. Neurosci. 22 (2): 271–83. doi:10.1016/s1044-7431(02)00027-1. PMID 12676536.
  11. Ye K, Compton DA, Lai MM, Walensky LD, Snyder SH (December 1999). "Protein 4.1N binding to nuclear mitotic apparatus protein in PC12 cells mediates the antiproliferative actions of nerve growth factor". J. Neurosci. 19 (24): 10747–56. doi:10.1523/JNEUROSCI.19-24-10747.1999. PMC 6784956. PMID 10594058.

Further reading


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