Nonossifying fibroma

A nonossifying fibroma is a common benign bone tumor in children and adolescents[1]. However, it is controversial whether it represents a true neoplasm or rather a developmental disorder of growing bone. Radiographically, the tumor presents as a well marginated radiolucent lesion, with a distinct multilocular appearance. These foci consist of collagen rich connective tissue, fibroblasts, histiocytes and osteoclasts. They originate from the growth plate, and are located in adjacent parts of the metaphysis and diaphysis of long bones, most often of the legs. No treatment is needed in asymptomatic patients and spontaneous remission with replacement by bone tissue is to be expected.

Nonossifying fibroma
Other namesFibroxanthoma
X-ray of nonossifying fibroma of distal tibia.
SpecialtyRheumatology 

Multiple nonossifying fibromas occur in Jaffe-Campanacci syndrome in combination with cafe-au-lait spots, mental retardation, hypogonadism, ocular and cardiovascular abnormalities.

The oldest case of nonossifying fibroma has been identified on the mandible of Qafzeh 9, an early anatomically modern human dated to 90–100 000 yrs B.P.[2]

Additional images
An ossified non-ossifying fibroma on CT
gollark: > using Facebook
gollark: Oh, and have it manage channel perms and overrides in a sane way too.
gollark: It might be good to just distribute/control roles through pyrobot somehow. Disable people's manual editing powers, group roles into cosmetic/individual person's/channel access/staff powers, and have commands for managing ones in each category.
gollark: Discord's permissions model is so very weird.
gollark: Idea: hide "administrator" in one of the color roles and see how long it is until someone notices.

See also

References
  1. Bowers, Leah M.; Cohen, Donald M.; Bhattacharyya, Indraneel; Pettigrew, James C.; Stavropoulos, Mary F. (25 September 2012). "The Non-ossifying Fibroma: A Case Report and Review of the Literature". Head and Neck Pathology. 7 (2): 203–210. doi:10.1007/s12105-012-0399-7. ISSN 1936-055X. PMC 3642261. PMID 23008139.
  2. Coutinho Nogueira D, Dutour O, Coqueugniot H, Tillier A.-m., (2019) Qafzeh 9 mandible (ca 90–100 kyrs BP, Israel) revisited : μ-CT and 3D reveal new pathological conditions, International Journal of Paleopathology, Vol 26, pp.104-110, https://doi.org/10.1016/j.ijpp.2019.06.002
Classification
External resources


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.