Schwannoma

A schwannoma is a usually benign nerve sheath tumor composed of Schwann cells, which normally produce the insulating myelin sheath covering peripheral nerves.

Schwannoma
Other namesneurilemoma,[1]:621 neuroma,[2] neurolemoma,[2] Schwann cell tumor[2]
Micrograph of a schwannoma showing both a cellular Antoni A area (center and right of image) and a loose paucicellular Antoni B area (left edge of image). HPS stain.
SpecialtyOncology 

Overview

Schwannomas are homogeneous tumors, consisting only of Schwann cells. The tumor cells always stay on the outside of the nerve, but the tumor itself may either push the nerve aside and/or up against a bony structure (thereby possibly causing damage). Schwannomas are relatively slow-growing. For reasons not yet understood, schwannomas are mostly benign and less than 1% become malignant, degenerating into a form of cancer known as neurofibrosarcoma. These masses are generally contained within a capsule, so surgical removal is often successful.[3]

Schwannomas can be associated with neurofibromatosis type II, which may be due to a loss-of-function mutation in the protein merlin.[4] They are universally S-100 positive, which is a marker for cells of neural crest cell origin.

Schwannomas of the head and neck are a fairly common occurrence and can be found incidentally in 3–4% of patients at autopsy.[4] Most common of these is a vestibular schwannoma, a tumor of the vestibulocochlear nerve that may lead to tinnitus and hearing loss on the affected side. Outside the cranial nerves, schwannomas may present on the flexor surfaces of the limbs. Rare occurrences of these tumors in the penis have been documented in the literature.[5]

Verocay bodies are seen histologically in schwannomas.

  • Subcutaneous schwannoma
  • Antoni A area of schwannoma with Verocay bodies (one annotated by circle)
gollark: I decided to look at the code in more detail. This was a mistake. It contained thousands of lines with minimally useful comments, for some reason its own implementation of hash tables (this is very C, I suppose), and apparently its own implementation of WiFi mesh things even though that should really be handled generically for any device.
gollark: After I was able to work through git's terrible CLI enough to make that work, and "fixed" some merge conflicts, it somehow compiled still, but upon plugging in the thing, hung things again. I had dmesg open, and apparently it was a page fault somehow in the code assigning names or something?
gollark: Then I noticed that they had merged patches a lot from the repo for a similar wireless chip, so I decided to just try and merge the "kernel 5.10 compatibility" thing from that, which had not made it in yet.
gollark: There was a repo on GitHub for doing that with it, but `insmod`ing it after compiling *somehow* hung my kernel so I had to reboot.
gollark: I mean, possibly. I wanted to get my USB WiFi thing to work in monitor mode for testing for non-evil purposes, but it was just really bad to do so.

See also

References
  1. James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
  2. Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
  3. Biswas, Deb (September 2007). "Extracranial head and neck schwannomas—A 10-year review". Auris Nasus Larynx. 34 (3): 353–359. doi:10.1016/j.anl.2007.01.006. PMID 17376620.
  4. Hanemann, CO (December 2006). "News on the genetics, epidemiology, medical care and translational research of Schwannomas". Journal of Neurology. 253 (12): 1533–1541. doi:10.1007/s00415-006-0347-0. PMID 17219030.
  5. Nguyen, Austin Huy; Smith, Megan; Maranda, Eric; Punnen, Sanoj (24 December 2015). "Clinical Features and Treatment of Penile Schwannoma: A Systematic Review". Clinical Genitourinary Cancer. 14 (3): 198–202. doi:10.1016/j.clgc.2015.12.018. PMID 26797586.
Classification
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