NLRP6

NLRP6, short for NOD-like receptor family pyrin domain containing 6, is an intracellular protein that plays a role in the immune system. It is also known as NALP6, PYPAF5, PAN3, and CLR11.4, and is one of 14 pyrin domain containing members of the NOD-like receptor family of pattern recognition receptors. As with several other NOD-like receptors, NLRP6's role in immunity is related to its ability to regulate caspase-1 and NF-κB activity.[5]

NLRP6
Identifiers
Aliases	NLRP6, AVR, CLR11.4, NALP6, NAVR, NAVR/AVR, PAN3, PYPAF5, NLR family, pyrin domain containing 6, NLR family pyrin domain containing 6
External IDs	OMIM: 609650 MGI: 2141990 HomoloGene: 15881 GeneCards: NLRP6
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 278,365 bp[1] End 285,359 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F5 Start 140,920,902 bp[2] End 140,929,192 bp[2]
Gene ontology Molecular function • nucleotide binding • vasopressin receptor activity • ATP binding Cellular component • cytoplasm • nuclear membrane • membrane • cell membrane • inflammasome • cell nucleus Biological process • response to bacterium • immune system process • wound healing • regulation of mucus secretion • negative regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of immune response • regulation of autophagy • negative regulation of toll-like receptor signaling pathway • negative regulation of inflammatory response to antigenic stimulus • regulation of inflammatory response • negative regulation of MAPK cascade • negative regulation of ERK1 and ERK2 cascade • innate immune system • inflammatory response • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	171389	101613
Ensembl	ENSG00000174885	ENSMUSG00000038745
UniProt	P59044	Q91WS2
RefSeq (mRNA)	NM_001276700 NM_138329	NM_001081389 NM_133946
RefSeq (protein)	NP_001263629 NP_612202	NP_598707
Location (UCSC)	Chr 11: 0.28 – 0.29 Mb	Chr 7: 140.92 – 140.93 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000174885 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038745 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Grenier JM, Wang L, Manji GA, et al. (October 2002). "Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1". FEBS Lett. 530 (1–3): 73–8. doi:10.1016/S0014-5793(02)03416-6. PMID 12387869.

Further reading

• Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
• Albrecht M, Domingues FS, Schreiber S, Lengauer T (2003). "Identification of mammalian orthologs associates PYPAF5 with distinct functional roles". FEBS Lett. 538 (1–3): 173–7. doi:10.1016/S0014-5793(03)00161-3. PMID 12633874.
• Tschopp J, Martinon F, Burns K (2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287.
• Wang L, Manji GA, Grenier JM, et al. (2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J. Biol. Chem. 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269.