NLRP5

NLRP5, short for NOD-like receptor family pyrin domain containing 5, is an intracellular protein that plays a role in early embryogenesis.[5][6] NLRP5 is also known as NACHT, LRR and PYD domains-containing protein 5 (NALP5), Mater protein homolog (MATER), PYPAF8, PAN11, and CLR19.8, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors known to mammals.

NLRP5
Identifiers
Aliases	NLRP5, CLR19.8, MATER, NALP5, PAN11, PYPAF8, NLR family, pyrin domain containing 5, NLR family pyrin domain containing 5
External IDs	OMIM: 609658 MGI: 1345193 HomoloGene: 65105 GeneCards: NLRP5
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.43 Start 55,999,726 bp[1] End 56,061,810 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A3|7 10.22 cM Start 23,385,889 bp[2] End 23,441,922 bp[2]
Gene ontology Molecular function • nucleotide binding • ATP binding Cellular component • cytoplasm • nucleolus • mitochondrion • cell nucleus Biological process • neuron death Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	126206	23968
Ensembl	ENSG00000171487	ENSMUSG00000015721
UniProt	P59047	Q9R1M5
RefSeq (mRNA)	NM_153447	NM_001039143 NM_011860 NM_001305857
RefSeq (protein)	NP_703148	NP_001034232 NP_001292786 NP_035990
Location (UCSC)	Chr 19: 56 – 56.06 Mb	Chr 7: 23.39 – 23.44 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

In humans, the NLRP5 protein is encoded by the NLRP5 gene.[7][8][9]

References

1. GRCh38: Ensembl release 89: ENSG00000171487 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015721 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wu X (February 2009). "Maternal depletion of NLRP5 blocks early embryogenesis in rhesus macaque monkeys (Macaca mulatta)". Hum. Reprod. 24 (2): 415–24. doi:10.1093/humrep/den403. PMID 19054779.
6. Pisani LF, Ramelli P, Lazzari B, Braglia S, Ceciliani F, Mariani P (February 2010). "Characterization of maternal antigen that embryos require (MATER/NLRP5) gene and protein in pig somatic tissues and germ cells". J. Reprod. Dev. 56 (1): 41–8. doi:10.1262/jrd.09-098a. PMID 19815987.
7. "Entrez Gene: NLR family".
8. Tong ZB, Bondy CA, Zhou J, Nelson LM (April 2002). "A human homologue of mouse Mater, a maternal effect gene essential for early embryonic development". Hum. Reprod. 17 (4): 903–11. doi:10.1093/humrep/17.4.903. PMID 11925379.
9. Tschopp J, Martinon F, Burns K (February 2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287.

Further reading

• Maraldi T, Riccio M, Sena P, et al. (2009). "MATER protein as substrate of PKCepsilon in human cumulus cells". Mol. Hum. Reprod. 15 (8): 499–506. doi:10.1093/molehr/gap048. PMID 19542546.
• Enjuanes A, Benavente Y, Bosch F, et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia". Cancer Res. 68 (24): 10178–86. doi:10.1158/0008-5472.CAN-08-2221. PMID 19074885.
• Alimohammadi M, Björklund P, Hallgren A, et al. (2008). "Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen". N. Engl. J. Med. 358 (10): 1018–28. doi:10.1056/NEJMoa0706487. PMID 18322283.
• Sena P, Riccio M, Marzona L, et al. (2009). "Human MATER localization in specific cell domains of oocytes and follicular cells". Reprod. Biomed. Online. 18 (2): 226–34. doi:10.1016/s1472-6483(10)60260-x. PMID 19192343.