Mycobacterium genavense

Mycobacterium genavense is a slow-growing species of the phylum Actinobacteria (Gram-positive bacteria with high guanine and cytosine content, one of the dominant phyla of all bacteria), belonging to the genus Mycobacterium.

Mycobacterium genavense
Scientific classification
Kingdom:
Bacteria
Phylum:
Actinobacteria
Order:
Actinomycetales
Suborder:
Corynebacterineae
Family:
Mycobacteriaceae
Genus:
Mycobacterium
Species:
M. genavense
Binomial name
Mycobacterium genavense
Böttger et al. 1993, ATCC 51234

Description

Nonmotile, acid-fast coccobacilli (1.0 µm x 2.0 µm). No formation of spores, capsules or aerial hyphae.

Colony characteristics

Physiology

  • Slow, fastidious growth in liquid media within 3–12 weeks at 31 °C, 37 °C and 42 °C, with slightly better growth at 45 °C.
  • Primary cultures for isolation require liquid broth media such as BACTEC 12B medium, Middlebrook 7H9 medium.
  • Acid broth media such as, BACTEC pyrazinamidase test medium, may facilitate primary isolation.
  • No growth on standard solid media like Löwenstein-Jensen, unsupplemented Middlebrook 7H11 or Middlebrook 7H10 media.
  • Visible growth on solid Middlebrook 7H11 medium supplemented with MJ after inoculation with a broth culture within 3–9 weeks.
  • Susceptible to streptomycin and rifampicin
  • Resistant to isoniazid and ethambutol

Differential characteristics

  • Differentiation from other slowly growing mycobacteria by its fastidious growth.
  • Closely related to M. simiae by evaluation of 16S rDNA sequences.

Pathogenesis
  • Opportunistic pathogen. Clinically indistinguishable from generalised infections in patients with AIDS due to M. avium complex strains, but more related to gastro-intestinal disorders.
  • Most common cause of mycobacterial disease in parrots and parakeets.

Type strain

Strain 2289 = ATCC 51234

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References
    • Böttger et al. 1993. Mycobacterium genavense sp. nov. Int. J. Syst. Bacteriol., 43, 841-843.


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