Mesuximide
Mesuximide (or methsuximide, methosuximide) is a succinimide anticonvulsant medication. It is sold as a racemate by Pfizer under the tradenames Petinutin (Switzerland)[1] and Celontin (United States).[2] The therapeutic efficacy of methosuximide is largely due to its pharmacologically active metabolite, N-desmethylmethosuximide, which has a longer half-life and attains much higher plasma levels than its parent.[3]
![]() | |
Clinical data | |
---|---|
Trade names | Celontin |
AHFS/Drugs.com | Consumer Drug Information |
MedlinePlus | a682028 |
Pregnancy category |
|
Routes of administration | By mouth (capsules) |
ATC code | |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Metabolism | Hepatic (demethylation and glucuronidation) |
Metabolites | N-desmethylmethosuximide |
Elimination half-life | 1.4–2.6 hours (mesuximide) 28–38 hours (active metabolite) |
Excretion | Urine |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.000.934 ![]() |
Chemical and physical data | |
Formula | C12H13NO2 |
Molar mass | 203.241 g·mol−1 |
3D model (JSmol) | |
Chirality | Racemic mixture |
| |
| |
![]() ![]() |
Medical use
is indicated for the control of absence seizures that are refractory to other drugs.[2]
gollark: Not *much* politics.
gollark: Yes, there's lots of interesting discussion.
gollark: I'm on desktop. It is not good on that.
gollark: Oh no. I accidentally refreshed the page, and now I am experiencing the horrors of the new UI.
gollark: I haven't actually personally experienced it, but apparently here in the UK the government handles the usual tax arrangements automatically instead of making you fill out all the paperwork, which seems good.
References
- Pfizer AG (2005). "Petinutin (Mésuximide)". Official Pfizer AG Website (in French). Archived from the original on April 22, 2005. Retrieved August 21, 2006.
- Pfizer Inc. (2008). "Celontin (methsuximide capsules, USP)". Official Pfizer Inc. Website. Retrieved November 21, 2014.
- Porter RJ, Penry JK, Lacy JR, Newmark ME, Kupferberg HJ. Plasma concentrations of phensuximide, methosuximide, and their metabolites in relation to clinical efficacy. Neurology 29: 1509-1513, 1979.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.