Mesenchyme

Mesenchyme (/ˈmɛsənkaɪm ˈmiːzən-/[1]) is a type of connective tissue found mostly during embryonic development of bilateral animals (triploblasts).[2] It is composed mainly of ground substance with few cells or fibers. It can also refer to a group of mucoproteins resembling mucus found, for example, in certain types of cysts. It is most easily found as a component of Wharton's jelly.

Mesenchyme
Transmission electron micrograph of mesenchyme displaying the ultrastructure of a typical cell and matrix.
Mesenchyme (pointer) stained with H&E
Details
Carnegie stage6b
PrecursorPrimarily mesoderm
Identifiers
TEE5.16.4.0.3.0.18
Anatomical terminology

The vitreous body of the eye is of a similar tissue.[3]

In invertebrate zoology, the term refers to free cells loosely arranged in a matrix.[4]

Terminology

"Mesenchyme" is a term introduced by Oscar Hertwig in 1881.[4]

In order to differentiate the use of the word mesenchyme in invertebrate zoology (an ecto- or entomesodermal middle layer of some invertebrates) and the use in vertebrate embryology (that is, undifferentiated tissue found in embryonic true mesoderm - entomesoderm - from which all connective tissues like blood vessels, blood cells, the lymphatic system, and the heart are derived.), some authors prefer to use the term mesoglea (in wider sense) in lieu of mesenchyme when referring to the middle layers of sponges and diploblasts, reserving the term mesenchyme for the embryological sense. However, Brusca & Brusca discourage this usage, using mesoglea in its strict sense (noncellular mesenchyme), and preferring to maintain both the embryological and zoological senses for the term mesenchyme.[5]

Finally, some similar terms used in botany generally are differentiated by the suffix "a": mesenchyma (a tissue between xylem and phloem in roots), collenchyma (primordial leaf tissues) and parenchyma (supportive tissues).[5]

Vertebrates

Structure

Mesenchyme is characterized morphologically by a prominent ground substance matrix containing a loose aggregate of reticular fibers and unspecialized mesenchymal stem cells.[6] Mesenchymal cells can migrate easily, in contrast to epithelial cells, which lack mobility, are organized into closely adherent sheets, and are polarized in an apical-basal orientation.

Development

The mesenchyme originates from the mesoderm.[7] From the mesoderm, the mesenchyme appears as an embryologically primitive "soup". This "soup" exists as a combination of the mesenchymal cells plus serous fluid plus the many different tissue proteins. Serous fluid is typically stocked with the many serous elements, such as sodium and chloride. The mesenchyme develops into the tissues of the lymphatic and circulatory systems, as well as the musculoskeletal system. This latter system is characterized as connective tissues throughout the body, such as bone, muscle and cartilage. A malignant cancer of mesenchymal cells is a type of sarcoma.[8][9]

Epithelial to mesenchymal transition
Main article: Epithelial–mesenchymal transition

The first emergence of mesenchyme occurs during gastrulation from the epithelial–mesenchymal transition (EMT) process. This transition occurs through the loss of epithelial cadherin, tight junctions, and adherens junctions on the cell membranes of epithelial cells.[10] The surface molecules undergo endocytosis and the microtubule cytoskeleton loses shape, enabling mesenchyme to migrate along the extracellular matrix (ECM). Epithelial–mesenchymal transition occurs in embryonic cells that require migration through or over tissue, and can be followed with a mesenchymal–epithelial transition to produce secondary epithelial tissues. Embryological mesenchymal cells expresses fibroblast-specific protein (Fsp1), which is indicative of their shared properties with the migratory adult fibroblasts, and c-Fos, an oncogene associated with the down-regulation of epithelial cadherin.[11][12] Both formation of the primitive streak and mesenchymal tissue is dependent on the Wnt/β-catenin pathway.[13] Specific markers of mesenchymal tissue include the additional expression of ECM factors such as fibronectin and vitronectin.[14]

Implantation

The first cells of the embryo to undergo EMT and form mesenchyme are the extra-embryonic cells of the trophectoderm. These migrate from the body of the blastocyst into the endometrial layer of the uterus in order to contribute to the formation of the anchored placenta.[15]

Primary mesenchyme

Primary mesenchyme is the first embryonic mesenchymal tissue to emerge, and it is produced from EMT in epiblast cells. In the epiblast, it is induced by the primitive streak through Wnt signaling, and produces endoderm and mesoderm from a transitory tissue called mesendoderm during the process of gastrulation.[16]

The formation of primary mesenchyme depends on the expression of WNT3. Other deficiencies in signaling pathways, such as in Nodal (a TGF-beta protein), will lead to defective mesoderm formation.[10]

The tissue layers formed from the primitive streak invaginate together into the embryo and the induced mesenchymal stem cells will ingress and form the mesoderm. Mesodermal tissue will continue to differentiate and/or migrate throughout the embryo to ultimately form most connective tissue layers of the body.[17]

Neural mesenchyme

Embryological mesenchyme is particularly transitory and soon differentiates after migration. Neural mesenchyme forms soon after primary mesenchyme formation.[18]

The interaction with ectoderm and somite-forming morphogenic factors cause some primary mesenchyme to form neural mesenchyme, or paraxial mesoderm, and contribute to somite formation. Neural mesenchyme soon undergoes a mesenchymal–epithelial transition under the influence of WNT6 produced by ectoderm to form somites.[19] These structures will undergo a secondary EMT as the somite tissue migrates later in development to form structural connective tissue such as cartilage and skeletal muscle.[20]

Neural crest cells (NCCs) form from neuroectoderm, instead of the primary mesenchyme, from morphogenic signals of the neural crest. The EMT occurs as a result of Wnt signaling, the influence of Sox genes and the loss of E-cadherin from the cell surface. NCCs additionally require the repression of N-cadherin, and neural cell adhesion molecule. NCCs ingress into the embryo from the epithelial neuroectodermal layer and migrate throughout the body in order form multiple peripheral nervous system (PNS) cells and melanocytes. Migration of NCCs is primarily induced by BMP signaling and its inhibitor, Noggin.[21][22]

Invertebrates

In some invertebrates, e.g., Porifera, Cnidaria, Ctenophora and some triploblasts (the acoelomates), the term "mesenchyme" refers to a more-or-less solid but looselly organized tissue consisting of a gel matrix (the mesoglea) with various cellular and fibrous inclusions, located between epidermis and gastrodermis. In some cases, the mesoglea is noncellular.[23]

  • In sponges, the mesenchyme is called mesohyl.[5]
  • In diploblasts (Cnidaria and Ctenophora), the mesenchyme is fully ectodermally derived. This kind of mesenchyme is called ectomesodermal, and is not considered true mesoderm.
  • In triploblastic acoelomates (e.g., flatworms), the term parenchyme is sometimes used for the middle (mesenchymal) layer, in which the dense layer includes tissues derived from both ecto- and entomesoderm (true mesoderm, derived from entoderm).

When cellular material is sparse or densely packed, the mesenchyme may be sometimes called collenchyme (e.g., cnidarians) or parenchyme (e.g., flatworms), respectively.[5] When no cellular material is present (e.g., in Hydrozoa), the layer is properly called mesoglea.[5]

In some colonial cnidarians, the mesenchyme is perforated by gastrovascular channels continuous among colony members. This entire matrix of common basal material is called coenenchyme.[5]

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References
  1. https://www.lexico.com/en/definition/mesenchyme
  2. "Blue Histology - Connective Tissues". Retrieved 2008-12-05.
  3. Singh, Inderbir (April 15, 2007). Textbook of Human Histology With Colour Atlas. Jaypee Brothers Medical Publishers. . ISBN 978-81-7179-967-1.
  4. Collins, P.; Billett, F. S. (1995). "The terminology of early development: History, concepts, and current usage". Clinical Anatomy. 8 (6): 418–425. doi:10.1002/ca.980080610. PMID 8713164.
  5. Brusca, R.C.; Brusca, G.J. (2003). Invertebrates (2nd ed.). Sunderland, Massachusetts. p. 220.
  6. Mesenchymal tissue
  7. Kierszenbaum, Abraham L.; Tres, Laura (2015). Histology and Cell Biology: An Introduction to Pathology E-Book (4 ed.). Elsevier Health Sciences. p. 123. ISBN 9780323313353.
  8. Strum, Judy M.; Gartner, Leslie P.; Hiatt, James L. (2007). Cell biology and histology. Hagerstown, MD: Lippincott Williams & Wilkins. p. 83. ISBN 978-0-7817-8577-8.
  9. Sadler, T.W. (2006). Langman's Medical Embryology. Lippincott Williams & Wilkins. pp. 68–70. ISBN 978-0-7817-9485-5.
  10. Kalluri, Raghu; Weinberg, Robert A. (2009). "The basics of epithelial-mesenchymal transition". Journal of Clinical Investigation. 119 (6): 1420–8. doi:10.1172/JCI39104. PMC 2689101. PMID 19487818.
  11. Okada, H; Danoff, T. M.; Kalluri, R; Neilson, E. G. (1997). "Early role of Fsp1 in epithelial-mesenchymal transformation". The American Journal of Physiology. 273 (4 Pt 2): F563–74. PMID 9362334.
  12. Eger, A; Stockinger, A; Schaffhauser, B; Beug, H; Foisner, R (2000). "Epithelial mesenchymal transition by c-Fos estrogen receptor activation involves nuclear translocation of beta-catenin and upregulation of beta-catenin/lymphoid enhancer binding factor-1 transcriptional activity". The Journal of Cell Biology. 148 (1): 173–88. doi:10.1083/jcb.148.1.173. PMC 3207144. PMID 10629227.
  13. Mohamed, O. A.; Clarke, H. J.; Dufort, D (2004). "Beta-catenin signaling marks the prospective site of primitive streak formation in the mouse embryo". Developmental Dynamics. 231 (2): 416–24. doi:10.1002/dvdy.20135. PMID 15366019.
  14. Thiery, J. P.; Sleeman, J. P. (2006). "Complex networks orchestrate epithelial-mesenchymal transitions". Nature Reviews Molecular Cell Biology. 7 (2): 131–42. doi:10.1038/nrm1835. PMID 16493418.
  15. Bellairs, R (1986). "The primitive streak". Anatomy and Embryology. 174 (1): 1–14. doi:10.1007/bf00318331. PMID 3518538.
  16. Hay, E. D. (2005). "The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it". Developmental Dynamics. 233 (3): 706–20. doi:10.1002/dvdy.20345. PMID 15937929.
  17. Mareschi, K; Novara, M; Rustichelli, D; Ferrero, I; Guido, D; Carbone, E; Medico, E; Madon, E; Vercelli, A; Fagioli, F (2006). "Neural differentiation of human mesenchymal stem cells: Evidence for expression of neural markers and eag K+ channel types". Experimental Hematology. 34 (11): 1563–72. doi:10.1016/j.exphem.2006.06.020. PMID 17046576.
  18. Schmidt, C; Stoeckelhuber, M; McKinnell, I; Putz, R; Christ, B; Patel, K (2004). "Wnt 6 regulates the epithelialisation process of the segmental plate mesoderm leading to somite formation". Developmental Biology. 271 (1): 198–209. doi:10.1016/j.ydbio.2004.03.016. PMID 15196961.
  19. Stockdale, F. E.; Nikovits Jr, W; Christ, B (2000). "Molecular and cellular biology of avian somite development". Developmental Dynamics. 219 (3): 304–21. doi:10.1002/1097-0177(2000)9999:9999<::AID-DVDY1057>3.0.CO;2-5. PMID 11066088.
  20. Bronner-Fraser, M (1994). "Neural crest cell formation and migration in the developing embryo". FASEB Journal. 8 (10): 699–706. doi:10.1096/fasebj.8.10.8050668. PMID 8050668.
  21. Trainor, P. A. (2005). "Specification of neural crest cell formation and migration in mouse embryos". Seminars in Cell & Developmental Biology. 16 (6): 683–93. doi:10.1016/j.semcdb.2005.06.007. PMID 16043371.
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