Technetium (99mTc) nofetumomab merpentan

Technetium (99mTc) nofetumomab merpentan (trade name Verluma) is a mouse monoclonal antibody derivative used in the diagnosis of lung cancer,[1] gastrointestinal, breast, ovary, pancreas, kidney, cervix, and bladder carcinoma.[2] The antibody part, nofetumomab, is attached to the chelator merpentan, which links it to the radioisotope technetium-99m (99mTc).[3]

Technetium (99mTc) nofetumomab merpentan
Monoclonal antibody
TypeFab fragment
SourceMouse
Clinical data
Trade namesVerluma
ATC code
  • none
Pharmacokinetic data
Elimination half-life10.5 hours
Excretionrenal (64%)
Identifiers
CAS Number
ChemSpider
  • none
UNII
 NY (what is this?)  (verify)

Nofetumomab

Nofetumomab is an antibody fragment that recognises the pancarcinoma glycoprotein antigen EpCAM.[4] and/or CD20/MS4A1[5]

It is the Fab part of murine MAb NR-LU-10.[6]

Merpentan

The chelator part : merpentan is a phenthioate ligand, 2,3,5,6-tetrafluorophenyl-4,5-bis-5-[1-ethoxyethyl]-thioacetoamidopentanoate.[6]

Phenthioate

Phenthioate is an insecticide (Cidial) = O,o-dimethyl-S-(carbethoxy-phenylmethyl)dithiophosphate[7]

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References
  1. Straka MR, Joyce JM, Myers DT (January 2000). "Tc-99m nofetumomab merpentan complements an equivocal bone scan for detecting skeletal metastatic disease from lung cancer". Clinical Nuclear Medicine. 25 (1): 54–5. doi:10.1097/00003072-200001000-00013. PMID 10634533.
  2. Breitz HB, Tyler A, Bjorn MJ, Lesley T, Weiden PL (September 1997). "Clinical experience with Tc-99m nofetumomab merpentan (Verluma) radioimmunoscintigraphy". Clinical Nuclear Medicine. 22 (9): 615–20. doi:10.1097/00003072-199709000-00007. PMID 9298295.
  3. "International Nonproprietary Names (INN) for pharmaceutical substances" (PDF). Geneva: World Health Organization. 2002.
  4. Tsurushita N, Vasquez M (January 2004). "Humanization of monoclonal antibodies". In Reth M, Radbruch A, Alt F, Honjo T, Neuberger M (eds.). Molecular Biology of B Cells. Academic Press. pp. 533–545. ISBN 978-0-08-047950-7.
  5. "Anti-MS4A1 Therapeutic Antibody (Technetium (99MTC) Nofetumomab Merpentan)". Creative BioLabs.
  6. Mudd E (27 February 2015). "Monoclonal Antibody Radionuclide Test Kits". Pharmacological Sciences.
  7. US 3934010, Drabek J, Varsanyi D, "Insecticidal composition and method utilizing phosphoric acid phenylsulphonamide esters", issued 20 January 1976, assigned to Ciba Geigy Corporation
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