Mark Wightman

Robert Mark Wightman (born July 4, 1947) is an electrochemist and professor of chemistry at the University of North Carolina at Chapel Hill. He is best known for his work in the areas of ultramicroelectrodes, electrochemistry, and neurochemistry. One of Wightman's most notable achievements is the development of the ultramicroelectrode and microelectrode voltammetry.[1] At the same time as Wightman's innovations, the microelectrode was developed independently by Martin Fleischmann at the University of Southampton. In 2011, Wightman had the 192nd highest h-index, 74, of any living chemist.[2] As of 2018, Wightman was an author of over 390 papers and had an h-index of 103.[3]

R. Mark Wightman
Born (1947-07-04) July 4, 1947
Dorchester, Dorset, England
Alma materErskine College (B.A.)

University of North Carolina (Ph.D.)

University of Kansas
AwardsFaraday Medal

Guggenheim Fellowship

Herty Medal
Scientific career
FieldsChemistry, electrochemistry, neurochemistry

Education and Academic Career

Education

Wightman received his B.A. degree with honors from Erskine College in Due West, South Carolina in 1968 and earned a Ph.D. in chemistry from the University of North Carolina at Chapel Hill in 1974, where he worked with Royce Murray. At UNC - Chapel Hill, Wightman began focusing his research on electrochemistry. Wightman was a postdoctoral researcher from 1974 to 1976 at the University of Kansas in Lawrence, Kansas under the direction of Ralph N. Adams. His work focused on electroanalytical methods and redox chemistry.[4]

Positions held

Wightman worked at Indiana University Bloomington in Bloomington, Indiana from 1976 to 1989. He worked as an assistant professor from 1976 to 1982, and he was promoted to the position of associate professor in 1982 and later to a full professor in 1985. He worked as a full professor until 1989 when he took a position at the University of North Carolina at Chapel Hill.[4]

Since 1989, Wightman has been the William R. Kenan Jr. professor of chemistry at the University of North Carolina at Chapel Hill. He was appointed to the neurobiology curriculum in 1989 and has held an external faculty position at the Neuroscience Center at UNC - Chapel Hill since 2004. He currently holds all three of these positions.[4]

Wightman also worked as a research associate at London Hospital Medical College at the University of London in 1984. He was a visiting professor at Duke University Medical Center in Durham, NC in 1997 and at the University of Cambridge in Cambridge, England in the anatomy department in 2004. Wightman was also a visiting fellow in the Churchill College at Cambridge in 2011. He has been an advisor for over 100 doctoral students, masters students, postdoctoral associates, and visiting faculty.[4]

Wightman has also been an editor for: Biosensors & Bioelectronics, Analytical Chemistry, Journal of Electroanalytical Chemistry, Journal of Pharmacology and Experimental Therapeutics, Synapse, and Annual reviews of Analytical Chemistry.

Current Research

The Wightman research group is primarily interested voltammetric sensors, particularly the ultramicroelectrode. Their small size allows for analysis and measurements at the level of a single biological cell. By coupling these electrodes to fast-scan voltammetric methods, the group has been able to monitor sub-second changes in concentrations of the neurotransmitters dopamine, norepinephrine, and serotonin in response to pharmacological and electrical stimuli.[5][6]

Awards and Achievements

Mark Wightman's awards include but are not limited to:

2011 - Herty Medal[7]

2010 - Sir Bernard Katz Award

2008 - American Chemical Society Award in Analytical Chemistry

2006 - Ralph N. Adams Award in Bioanalytical Chemistry

2002 - American Association for the Advancement of Science Fellow

1999 - Erskine College Academic Hall of Fame

1996 - Guggenheim Fellowship[8]

1979-1983 - National Institutes of Health Research Career Development Award

1981-1983 - Alfred P. Sloan Fellowship

Notable Papers

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

Subsecond dopamine release promotes cocaine seeking

Detection of dopamine dynamics in the brain

Microvoltammetric electrodes

Patents

Wightman holds two patents through the United States Patent and Trademark Office, patents 4,038,158 and 4,041,346. Both patents are listed under the name: electrochemical generation of field desorption emitters.[9][10]

gollark: Computer algebra systems in general?
gollark: It's running on a device which is *so much better than this* and yet it has moderately suboptimal button stuff designed for physical devices, and *pixelated display stuff*.
gollark: How moderately beeoidal.
gollark: PotatOS incorporates a prime factorization program which can handle numbers up to 2^40, which isn't very big but it runs on floats.
gollark: UTTERLY miller-rabin yourself?

References
  1. "Microvoltammetric Electrodes" (PDF). Analytical Chemistry. August 1981.
  2. "H-index ranking of living chemists" (PDF). Chemistry World. 12 December 2011.
  3. "Scopus, Author Details - Wightman, Robert Mark"
  4. "Curriculum Vitae of Robert Mark Wightman" (PDF). Retrieved April 26, 2018.
  5. Kirkpatrick, D. C.; McKinney, C. J.; Manis, P. B.; Wightman, R. M. (2016-08-02). "Expanding neurochemical investigations with multi-modal recording: simultaneous fast-scan cyclic voltammetry, iontophoresis, and patch clamp measurements". The Analyst. 141 (16): 4902–4911. doi:10.1039/c6an00933f. ISSN 1364-5528. PMC 5134327. PMID 27314130.
  6. Bucher, Elizabeth S.; Wightman, R. Mark (2015-07-10). "Electrochemical Analysis of Neurotransmitters". Annual Review of Analytical Chemistry. 8 (1): 239–261. doi:10.1146/annurev-anchem-071114-040426. ISSN 1936-1327. PMC 4728736. PMID 25939038.
  7. "Herty Award To Mark Wightman | April 18, 2011 Issue - Vol. 89 Issue 16 | Chemical & Engineering News". cen.acs.org. Retrieved 2018-04-24.
  8. "Search Results - John Simon Guggenheim Memorial Foundation". 2012-10-02. Archived from the original on 2012-10-02. Retrieved 2018-04-24.
  9. "Patent Images". pdfpiw.uspto.gov. Retrieved 2018-04-24.
  10. "Patent Images". pdfpiw.uspto.gov. Retrieved 2018-04-24.
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